Equine herpesvirus vaccine
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorMark W. Mellencamp
Life of this patent
Estimating the term…
Abstract
A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.
Claims20
A vaccine for protecting a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising:
- chemically inactivated EHV-1 KyA virus;
- and
- an adjuvant.
A method of producing an equine herpesvirus vaccine comprising:
- (a) inoculating simian cells with an EHV-1 KyA virus;
- (b) incubating the inoculated simian cells;
- (c) harvesting EHV-1 KyA virus from the incubated cells;
- and
- (d) treating the harvested cells with a chemical inactivating agent which includes a compound selected from the group consisting of ethylenimine, binary ethylenimine, acetylethylenimine or a mixture thereof to form inactivated EHV-1 KyA virus.
A vaccine for protecting a horse against diseases associated with equine herpesviruses and equine influenza virus comprising:
- chemically inactivated EHV-1 KyA virus;
- inactivated EHV-4 virus;
- inactivated EIV virus;
- and
- an adjuvant.
A method for protecting a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising administering a vaccine comprising:
- (a) chemically inactivated EHV-1 KyA virus;
- and
- (b) an adjuvant.
A kit for vaccinating a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising:
- (a) a dispenser capable of administering a vaccine to a horse;
- and
- (b) a vaccine comprising chemically inactivated EHV-1 KyA and an adjuvant, wherein the vaccine is capable of protecting a horse against diseases associated with EHV-1 and EHV-4.
A kit for detecting EHV-1 and EHV-4 in a test sample comprising:
- (a) a first monoclonal antibody that immunoreacts with EHV-1 to form a first complex;
- (b) a second monoclonal antibody that inimunoreacts with EHV-4 to form a second complex;
- and
- (c) at least one detectable label for use in detecting the first complex, the second complex, or both complexes.
Dependencies are inferred from the claim text.