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US 7,226,602 B2Granted
Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsStephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney
Life of this patent
Estimating the term…
Abstract
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
Claims13
A temperature-sensitive, host-range restricted mutant flavivirus, designated mutant 200, 201, wherein said virus comprises charge-cluster-to-alanine mutations at amino acids 2687 and 2688 of the NS5 gene, where amino acid position is given for the polyprotein of dengue virus type 4.
Dependencies are inferred from the claim text.