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US 7,223,730 B2Granted
Antithrombosis enzyme from the snake venom of agkistrodon acutus
AssigneeHefei-Siu-Fung USTC Pharmaceutical Co., Ltd.
InventorsChun Wang, Benjamin Xy Li, Xin Cheng, Jing Liu, Li-Wen Niu, Wan-Zhi Huang, Zhen-Yu Xu, Dan Luo, Lian-Di Kang, Jin-Guo Ding, Fang Rong, Yan Liu, Hui-Ran Chen
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Abstract
This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.
Claims12
A method for dissolving a thrombus in a mammal, comprising the step of administering to said mammal a pharmaceutically effective amount of an isolated, purified or recombinant antithrombosis enzyme having the following characteristics:
- the molecular weight of said enzyme is between about 28 kD and about 32 kD when analyzed by polyacrylamide gel electrophoresis,
- the aspartic acid content of said enzyme is between about 2% and about 5%,
- the glutamic acid content of said enzyme is between about 2% and about 5%
- said enzyme hydrolyzes fibrin, dissolves blood clots, and Prevents platelet aggregation.
1 more element
Dependencies are inferred from the claim text.