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US 7,223,593 B2Granted
Herpes virus strains for gene therapy
AssigneeBiovex Limited
InventorRobert Stuart Coffin
Life of this patent
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Abstract
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.
Claims4
A herpes simplex virus which:
- (i) comprises a gene encoding an immunostimulatory protein;
- (ii) lacks a functional ICP34.5 encoding gene and a functional ICP47 encoding gene;
- (iii) is replication competent in tumor cells;
- and
- (iv) is derived from HSV1 JS1 as deposited at the European collection of cell cultures (ECAAC) under accession number 01010209.
2 more elements
HSV1 strain JS1 as deposited at the European Collection of Cell Cultures (ECACC) under accession number 01010209, or an HSV1 strain derived therefrom.
Dependencies are inferred from the claim text.