Myeloperoxidase, a risk indicator for cardiovascular disease

A method of assessing a test subject's risk of having atherosclerotic cardiovascular disease, comprising

• comparing levels of myeloperoxidase in a bodily sample from the test subject with levels of myeloperoxidase in comparable bodily samples from control subjects diagnosed as not having the disease, said bodily sample being blood, serum, plasma, blood leukocytes selected from the group consisting of neutrophils, monocytes, sub-populations of neutrophils, and sub-populations of monocytes, or any combination thereon;
• wherein the levels of myeloperoxidase in the bodily from the test subject relative to the levels of nayeloperoxidase in the comparable bodily samples from control subjects is indicative of the extent of the test subject's risk of having atherosclerotic cardiovascular disease.

A method of assessing a test subject's risk of developing a complication of atherosclerotic cardiovascular disease comprising:

• determining levels of myeloperoxidase (MPO) activity, myeloperoxidase (MPO) mass, or both in a bodily sample of the test subject, said bodily sample being blood, serum, plasma, blood leukocytes selected from the group consisting of neutrophils and monocytes, or any combination thereof;
• wherein elevated levels of MPO activity or MPO mass or both in the test subject's bodily sample as compared to levels of MPO activity, MPO mass, or both, respectively in comparable bodily samples obtained from control subjects diagnosed as not having the disease indicates that the test subject is at risk of developing a complication of atherosclerotic cardiovascular disease.

A method for characterizing a test subject's risk of having atherosclerotic cardiovascular disease, comprising:

• determining levels of myeloperoxidase (MPO) activity, myeloperoxidase (MPO) mass, or both in a bodily sample from the test subject, wherein the bodily sample is blood, serum, or plasma, and
• wherein elevated levels of MPO activity or MPO mass or both in the subject's bodily sample as compared to levels of MPO activity, MPO mass or both, respectively, in comparable bodily samples obtained from control subjects indicates that the test subject is at risk of having atherosclerotic cardiovascular disease.

A method of characterizing a test subject's risk of having atherosclerotic cardiovascular disease comprising:

• determining levels of myeloperoxidase (MPO) activity, myeloperoxidase (MPO) mass, or both in a bodily sample from the test subject, said bodily sample being blood, serum, plasma, neutrophils or monocytes;
• wherein a test subject whose bodily sample contains levels of MPO activity or MPO mass or both that are higher than a control value based on levels of MPO activity, MPO mass or both, respectively, in comparable bodily samples obtained from control subjects diagnosed as not having the disease is at greater risk of having cardiovascular disease than a test subject whose bodily sample contains levels of MPO activity or MPO mass or both that are equal to or less than the control value.

A method for characterizing a test subject's risk of developing atherosclerotic cardiovascular disease, comprising:

• determining levels of myeloperoxidase (MPO) activity, myeloperoxidase (MPO) mass, or both in a bodily sample from the test subject, said bodily sample being blood, serum, plasma, blood leukocytes selected from the group consisting of neutrophils, monocytes, and a combination thereof,
• wherein elevated levels of MPO activity or MPO mass or both in the bodily sample of the test subject as compared to at least one value based on levels of MPO activity, MPO mass or both, respectively, in comparable bodily samples obtained from control subjects diagnosed as not having the disease indicates that the test subject is at risk of developing atherosclerotic cardiovascular disease.

A method for characterizing a test subject's risk of developing atherosclerotic cardiovascular disease, comprising:

• determining levels of myeloperoxidase (MPO) activity, myeloperoxidase (MPC)) mass, or both in a bodily sample from the test subject, said bodily sample being blood, serum, plasma, blood leukocytes selected from the group consisting of neutrophils, monocytes, sub-populations of neutrophils, and sub-populations of monocytes or any combination thereof,
• wherein elevated levels of MPO activity or MPO mass or both in the bodily sample of the test subject as compared to at least one value based on levels of MPO activity, MPO mass or both, respectively, in comparable bodily samples obtained from control subjects diagnosed as not having the disease indicates that the test subject is at risk of developing atherosclerotic cardiovascular disease.