Compositions and methods for treatment of cancer
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Theravir Management L.P.
InventorsZichria Zakay-Rones, Amos Panet, Charles Irving
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Abstract
The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. Another feature of the invention is the use of at least one isolated viral glycoprotein or a subunit or analog thereof or of an isolated polynucleotide encoding the same for the treatment of cancer.
Claims10
An isolated lentogenic oncolytic strain of Newcastle Disease Virus (NDV) comprising the DNA nucleotide sequence of SEQ ID NO:
- 1 encoding for the fusion (F) gene and at least part of the hemaglutinin-neuraminidase (HN) gene.
Dependencies are inferred from the claim text.