Methods and devices for epithelial protection during photodynamic therapy
AssigneeThe General Hospital Corporation
InventorsRichard Rox Anderson, Bernhard Ortel, Eliot F. Battle, Edwin K. Joe
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Abstract
Methods for preventing damage to epithelial tissue during PDT induced using a photosensitizing agent or pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control photoactivation of the photoactive species to protect the epithelial tissue. In one embodiment, epithelial tissue surrounding a targeted treatment site can be protecting by decreasing the oxygen-content in the tissue, thereby preventing the conversion of the photosensitizer into the phototoxic species in the epithelial tissue.
Claims13
A method for inhibiting phototoxicity of a photosensitizing agent in non-targeted tissue during photodynamic therapy using the photosensitizing agent or a pre-photosensitizing agent, the method comprising the steps of:
- administering an agent to a targeted treatment site, the agent being effective to accumulate in tissue at the targeted treatment site as a photosensitizing agent;
- and irradiating the targeted treatment site to activate the photosensitizing agent to cause phototoxicity in tissue at the targeted treatment site while inhibiting phototoxicity of the photosensitizing agent in non-targeted tissue surrounding the targeted treatment site, wherein the step comprises reducing the oxygen-content in the non-targeted tissue during the step of irradiating the treatment site.
Dependencies are inferred from the claim text.