Methods and compositions for applying pharmacologic agents to the ear
AssigneeRegents of the University of Minnesota
InventorsRonald J. Sawchuk, Belinda W. Y. Cheung
Life of this patent
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Abstract
Methods and materials useful for applying pharmacologic agents to the ear are described. The methods involve delivering a composition that contains at least one viscogenic agent and at least one pharmacologic agent to the epidermal surface of the tympanic membrane via the ear canal. The composition is delivered to the tympanic membrane in a flowable form and, after delivery to the tympanic membrane, becomes sufficiently viscous such that the pharmacologic agent is localized against the tympanic membrane. Such compositions can be used to prophylactically and/or therapeutically treat middle and inner ear conditions, including otitis media.
Claims25
A method for administering a pharmacologic agent to the middle ear of a mammal, said method comprising applying a formulation to the epidermal surface of a tympanic membrane of said mammal, wherein said formulation is aqueous and comprises a viscogenic agent and at least one pharmacologic agent, wherein said formulation is flowable and has a viscosity less than 100,000 cps, and wherein said formulation, after application to said tympanic membrane, forms a gel that has a yield stress sufficient to maintain said formulation against said tympanic membrane, wherein said pharmacologic agent transfers across said tympanic membrane into the middle ear space.
Dependencies are inferred from the claim text.