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US 7,220,401 B2Granted
Blood clot-targeted nanoparticles
AssigneeBarnes-Jewish Hospital
InventorsGregory Lanza, Samuel A. Wickline
Life of this patent
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Abstract
Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents.
Claims13
A method to obtain a magnetic resonance image of a blood clot in a subject, which method comprises
- administering to said subject an emulsion of nanoparticles, said nanoparticles consisting of liquid perfluorocarbon coated with lipid/surfactant,
- wherein said nanoparticles are coupled to at least one targeting ligand that is specific for at least one component characterizing blood clots that binds specifically to fibrin, gpIIb/IIIa, tissue factor/VIIA complex, activated clotting factor Xa, activated clotting factor IXa, or the fibrin condensation product, d-dimer, and
- wherein said nanoparticles are also coupled to at least one magnetic resonance imaging (MRI) contrast agent;
- allowing the targeting ligand to bind to the blood clot;
- and
- detecting a magnetic resonance image of said blood clot wherein said blood clot is bound to said ligand coupled directly to said lipid/surfactant-coated particles, while said nanoparticles are entirely in the liquid state.
3 more elements
Dependencies are inferred from the claim text.