Disposable sensor for use in measuring an analyte in a gaseous sample
AssigneeApieron Biosystems Corp.
InventorsBryan Flaherty, Bhairavi Parikh, Kevin Nason, David Chazan, Johnathan Fay, John Kaiser, James Stone
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Abstract
The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.
Claims14
A method of measuring the concentration of nitric oxide in a range of 5 to 200 ppb in a gas sample of exhaled breath, said method comprising:
- providing a first disposable sensor, said first sensor comprising a sensing element comprising cytochrome-c in a sol-gel, wherein said sensing element undergoes a change in the presence of 5 to 200 ppb of nitric oxide;
- loading said first sensor into a gas analysis device;
- measuring the concentration of nitric oxide in an exhaled breath sample using said first disposable sensor and said gas analysis device;
- removing said first disposable sensor from said device;
- and
- installing a second disposable sensor into said device, said second disposable sensor likewise comprising a sensing element comprising cyrochrome-c and a sol-gel and undergoing a change in the presence of 5 to 200 ppb of nitric oxide.
A device for quantifying the concentration of nitric oxide in a range of 5 to 200 ppb in a gaseous sample of exhaled breath, said device comprising:
- a disposable sensing element comprising cytocbrome-c in a sol-gel and having a nitric oxide measurement range of 5 to 200 ppb;
- and
- an interface means for interfacing said disposable sensing element with the remainder of said device.
A kit for determining the concentration of nitric oxide in a sample of exhaled breath in which said nitric oxide is present in an amount ranging from 5 to 200 ppb, said kit comprising:
- a plurality of disposable sensors, wherein said sensors comprise cytochrome-c in a sol-gel having a nitric oxide response range of 5 to 200 ppb;
- a gas analysis device for use with said sensors, said device comprising means for receiving exhaled breath and converting said response to a measurable signal.
Dependencies are inferred from the claim text.