Human gene critical to fertility
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsLawrence M. Nelson, Zhi-Bin Tong
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Abstract
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
Claims5
An isolated nucleic acid molecule encoding a human MATER protein comprising the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.