Multivalent dengue virus vaccine
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsKenneth H. Eckels, Joseph B. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, Wellington Sun, Niranjan Kanesa-Thasan
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Abstract
The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
Claims13
A method for stimulating dengue virus specific immune response, which comprises administering to an individual an immunologically sufficient amount of two or more attenuated viruses chosen from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-27 having the ATCC accession number PTA-4810, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-6 having the ATCC accession number PTA-4811, and a physiologically acceptable vehicle.
A method for stimulating dengue virus specific immune response, which comprises administering to an individual an immunologically sufficient amount of two or more attenuated viruses chosen from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-27 having the ATCC accession number PTA-4810, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-20 having the ATCC accession number VR-2652, and a physiologically acceptable vehicle.
A method for stimulating dengue virus specific immune response, which comprises administering to an individual an immunologically sufficient amount of two or more attenuated viruses chosen from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-20 having the ATCC accession number VR-2648, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-20 having the ATCC accession number VR-2652, and a physiologically acceptable vehicle.
A method for stimulating dengue virus specific immune response, which comprises administering to an individual an immunologically sufficient amount of two or more attenuated viruses chosen from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-20 having the ATCC accession number VR-2648, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-6 having the ATCC accession number PTA-4811, and a physiologically acceptable vehicle.
Dependencies are inferred from the claim text.