Vasculostatic agents and methods of use thereof

A compound of structure (III):

• wherein:
• each of Z2 and Z4 is C, each of Z1, Z3, Z5, and Z6 is N;
• each X is NH2;
• each Y is independently selected from a group consisting of —ORd, —NRd2, —SRd, and —OPO3H2, wherein Rd is selected from a group consisting of H, lower alkyl, aryl, and —(CH2)2NH(CH2CH3);
• or
• each Y is independently selected from a group consisting of alkyl, substituted alkyl, aryl, substituted aryl, and halogen, wherein said substituents are selected from a group consisting of halogen, —ORe, —NRe2, —SRe, and —P(O)(OH)2, wherein Re is selected from a group consisting of —H, lower alkyl, and aryl;
• or
• each Y is independently selected from a group consisting of CH2glycinyl, CH2NHethoxy, CH2NHCH2alkyl, CH2NHCH2t-Bu, CH2NHCH2aryl, and CH2NHCH2substituted aryl;
• or
• when n is 2, each Y is taken together to form a fused aromatic ring system;
• and
• m and n are each independently 1 to 4,
• wherein when m=n=2, Y is not phenyl or 4-hydroxyphenyl, or tautomers thereof.