Method of loading beneficial agent to a prosthesis by fluid-jet application

A method of loading beneficial agent onto a prosthesis for delivery within a lumen, the method comprising the steps of:

• providing a prosthesis to be deployed within a lumen, the prosthesis including a tubular member having a central axis of rotation defined along a length thereof;
• providing beneficial agent to be delivered from the prosthesis;
• providing a fluid-dispenser having a dispensing element for dispensing beneficial agent in discrete droplets;
• dispensing beneficial agent from the dispensing element along a controlled trajectory to a surface of the prosthesis, wherein the controlled trajectory of beneficial agent does not intersect the central axis of rotation of the prosthesis and wherein the dispensing element and the prosthesis are separated by a distance that avoids simultaneous contact of the dispensing element and the surface of the prosthesis by a discrete droplet;
• and
• determining an amount of beneficial agent loaded on a prosthesis, wherein the determining step includes detecting an amount of identifiable marker loaded onto the prosthesis to determine a corresponding amount of beneficial agent loaded on to the prosthesis.