Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for producing thereof
AssigneeChisso Corporation
InventorsMasakatsu Shibasaki, Hiroaki Sasai, Yasuo Urata, Mamoru Fujita
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Abstract
Optically active 1-substituted phenyl-2-nitro alcohol derivatives having the formula (1) and the process for producing thereof, and 1-substituted phenyl-2-amino alcohol derivatives having the formula (2) and the process for producing thereof from the optically active 1-substituted phenyl-2-nitro alcohol derivatives. From these nitro alcohols, pharmaceuticals such as (R)-albutamin and (R)-sarmeterol useful as a bronchodilator is obtained via optically active amino alcohols which are useful pharmaceutical intermediates.
Claims2
Optically active 1-(3-hydroxymethyl-4-hydroxyphenyl)-2-nitro alcohol derivatives characterized by the following formula (1-2)
- in which R1 and R2 represent a hydrogen atom or a hydroxyl-protective group, respectively, and they are independent of each other or form a ring;
- R4 represents a hydrogen atom, an alkyl group, or a hydroxymethyl group;
- and * represents an optically active site, and when R4 is a hydrogen atom, optical activity at the site to which R4 is added is lost and * is omitted.
Dependencies are inferred from the claim text.