Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham, Kristina Lemonidis Tarbet
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
Claims18
An antisense compound 12 to 30 nucleobases in length targeted to a nucleic acid molecule encoding acyl CoA cholesterol acyltransferase-2, wherein said compound is fully complementary to at least an 8-nucleobase portion of nucleotides 161 to 190 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.