US 7,202,350 B2 · C-glycoside derivatives and salts thereof

Abstract

The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

Claims3

Dependent claims

A C-glycoside derivative of the following formula or a salt thereof:

wherein:
R6 represents a hydrogen atom, halogen atom, —OH, —O-lower alkyl, -lower alkylene-OH, —O-lower alkylene-OH, —O-lower alkylene-NH2,—COOH, —COO-lower alkyl, —O-lower alkylene-COOH, or —O-lower alkylene-COO-lower alkyl,
R7 represents a hydrogen atom or halogen atom,
R8 represents a hydrogen atom or -lower alkyl, and
R9 represents a hydrogen atom, -lower alkyl, halogen atom, or —O-lower alkyl.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/541,615Filed 12 Mar 2004

Priority

JP 2003-07029714 Mar 2003

Published

US 2006/0122126 A18 Jun 2006

Granted

10 Apr 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

C07D 495/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring
A61K 31/381
Having sulfur as a ring hetero atom: having five-membered rings
A61K 31/4035
Condensed with carbocyclic rings, e.g. carbazole: isoindoles, e.g. phthalimide

C-glycoside derivatives and salts thereof

Life of this patent

C-glycoside derivatives and salts thereof

Life of this patent

Abstract

Claims3