Back to results
US 7,202,257 B2Granted
Anti-inflammatory medicaments
AssigneeDeciphera Pharmaceuticals, LLC
InventorsDaniel L. Flynn, Peter A. Petillo
Life of this patent
Estimating the term…
Abstract
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.
Claims3
A compound having the formula
- wherein:
- A is selected from the group consisting of phenyl, naphthyl, pyridyl, pyrimidyl, thienyl, furyl, pyrrolyl, thiazolyl, isothiazolyl, oxaxolyl, isoxazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, indolyl, indazolyl, benzimidazolyl, benzotriazolyl, isoquinolyl, quinolyl, benzothiazolyl, benzofuranyl, benzothienyl, pyrazolylpyrimidinyl, imidazopyrimidinyl, purinyl, and
- where each W1 is individually selected form the group consisting of —CH— and —N;
- R6 is selected from the group consisting of —H and alkyls;
- D is a five-membered ring having at least one nitrogen atom therein;
- R7″ is selected from the group consisting of alkyls, aryls, heterocyclyls, and perfluoroalkyls;
- Q is Q47;
- each R9 group is individually selected from the group consisting of —H, —F, and alkyls, wherein when two R9 groups are geminal alkyl groups, said geminal alkyl groups may be cyclized to form a 3–6 membered ring;
- and
- wherein A or Q47 is optionally substituted with one or more of R7′ substituents selected from the group consisting of —H, alkyls, aryls, heterocyclyls, alkylaminos, cycloalkylaminos, hydroxyls, alkoxys, perfluoroalkoxys, alkylthios, cyanos, halogens, alkylsulfinyls, alkylsulfonyls, aminosulfonyls, perfluoroalkyls;
- aminooxaloylamino;
- piperazinooxaloylamino;
- or aminoalkyloxycarbonylamino.
10 more elements
Dependencies are inferred from the claim text.