Drug therapy for celiac sprue
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsLudvig M. Sollid, Chaitan Khosla, Hanne Quarsten, Chu-Young Kim
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Abstract
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) retain the to bind tightly to HLA molecules; (ii) retain the protcolytic stability of these peptides; but (iii) are unable to T cells.
Claims3
A computer-assisted method for identifying potential modulators of Celiac Sprue and/or dermatitis herpetiformis, using a programmed computer comprising a processor, a data storage system, an input device, and an output device, comprising the steps of:
- (a) inputting Into the programmed computer through said input device data comprising the three-dimensional coordinates of a subset of the atoms, generated from a complex of DQ2 molecule bound to an immunogenic gluten oligopeptide selected from the group consisting of PFPQPQLPY (SEQ ID NO:
- 12);
- PQPQLPYPQ (SEQ ID NO:
- 13);
- PFPQPQLPY (SEQ ID NO:
- 14);
- PQPQLPYPQ (SEQ ID NO:
- 15);
- PYPQPELPY (SEQ ID NO:
- 16);
- and PYPQPQLPY (SEQ ID NO:
- 17) PYPQPQLPY, thereby generating a criteria data set;
- (b) comparing, using said processor, said criteria data set to a computer database of chemical structures stored in said computer data storage system;
- (c) selecting from said database, using computer methods, chemical structures having a portion that is structurally similar to said criteria data set;
- (d) outputting to said output device the selected chemical structures having a portion similar to said criteria data set.
Dependencies are inferred from the claim text.