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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAlexander C. Schmidt, Mario H. Skiadopoulos, Peter L. Collins, Brian R. Murphy, Jane E. Bailly, Anna P. Durbin
Estimating the term…
Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response or as vectors for introducing heterologous genes into a host. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete “background” PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome.
An infectious human-bovine chimeric parainfluenza virus (PIV) comprising a major nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large polymerase protein (L), and a partial or complete chimeric human PIV3 (HPIV3)-bovine PIV3 (BPIV3) genome or antigenome, in which said partial or complete PIV genome or antigenome comprises a polynucleotide encoding a wild-type L protein.
An isolated polynucleotide comprising a polynucleotide encoding a partial or complete chimeric human PIV3 (HPIV3)-bovine PIV3 (BPIV3) genome or antigenome, in which said partial or complete chimeric genome the or antigenome comprises a polynucleotide encoding a wild-type L protein.
Dependencies are inferred from the claim text.