Localized two-dimensional shift correlated MR spectroscopy of human brain
AssigneeThe Regents of the University of California
InventorsMichael Albert Thomas, Kenneth Yue
Life of this patent
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Abstract
A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°-180°-90°) for whole body MR Spectroscopy. Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. A combination of different MRI transmit/receive rf coils is used. The cross peak intensities excited by the proposed 2D sequence are asymmetric with respect to the diagonal peaks. Localized COSY spectra of cerebral frontal and occipital gray/white matter regions in fifteen healthy controls are presented.
Claims11
A method of whole body magnetic resonance (MR) spectroscopy utilizing localized chemical shift correlated magnetic resonance spectroscopic sequence (L-COSY), said L-COSY sequence comprising the steps of:
- a) applying a pulse train of at least three high frequency (rf) pulses to localize in one shot a volume of interest, a first slice selective 90° rf pulse, a second slice selective 180° rf pulse and a last slice selective 90° rf pulse, wherein the first and second slice selective rf pulses generate a first spin echo and the last slice selective 90° rf pulse generates a second echo that is a coherent transfer echo;
- b) inserting an incremental period t1 after the first spin echo and before the last slice selective 90° pulse;
- and
- c) detecting a MR signal during interval t2 after the last slice-selective 90° rf pulse and storing the MR signal data.
The method of claim of 6, further comprising extracting a cross-sectional one dimensional (1 D) MR spectra of a metabolite from the 2D L-COSY spectrum.
A method of volume localization performed on a magnetic resonance imaging (MRI) scanner utilizing a coherence transfer based spin-echo spectroscopy (CABINET) sequence, said CABINET sequence comprising the steps of:
- a) applying a pulse train of at least three high frequency (rf) pulses to localize in one shot a volume of interest, a first slice selective 90° rf pulse, a second slice selective 180° rf pulse and a last slice selective 90° rf pulse, wherein the first and second slice selective if pulses generate a first spin echo and the last slice selective 90° rf pulse generates a second echo that is a coherent transfer echo;
- b) inserting an incremental period t1 after the first spin echo and before the last slice selective 90° pulse;
- and
- c) detecting a MR signal during interval t2 after the last slice-selective 90° rf pulse and storing the MR signal data.
Dependencies are inferred from the claim text.