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US 7,199,238 B2Granted
LPAAT-β inhibitors and uses thereof
AssigneeCell Therapuetics, Inc.
InventorsLynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J. Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
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Abstract
The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
Claims7
A compound of the Formula:
- wherein,
- R1 is hydroxy, alkylmercapto, or mercapto;
- R2 and R4 are hydrogen;
- and R3 and R5, which may be same or different, are aryl or aryl substituted with 1 to 3 substituents selected from hydroxy, alkoxy and halogen;
- or
- pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.