Compositions and methods
AssigneeThomas Sai Ying Ko
InventorThomas Sai Ying Ko
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Abstract
Non-aerosol spray-on skin patch compositions as described comprising at least one substantially water insoluble film forming agent, at least one film plasticizer agent, at least one water soluble compound, and at least one organic solvent, the composition forming a flexible, porous and physiologically compatible skin patch when sprayed on to skin and allowed to dry. Also described are methods of improving wound healing by administering a physiologically active ingredient to a patient in need of such treatment.
Claims17
A non-aerosol sprayable skin patch composition consisting essentially of:
- (a) 0.01% to 10% w/w of at least one water-soluble physiologically active ingredient;
- (b) 1% to 50% w/w of at least one substantially water insoluble film forming agent selected from the group consisting of acrylic acid, polyacrylic acid, polybutylmethacrylate, polymethacrylic acid, ascorbyl palmitate, carbomer, cellulose acetate phthalate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethyl cellulose, hydroxypropyl methlycellulose phthalate, hypomellose phthalate, crospovidone, cetyl alcohol, poloaxmer, polyethylene glycol, polyvinyl acetate, polyvinyl acetate phthalate, polyvinyl alcohol, and povidone;
- (c) 0.1% to 20% w/w of at least one film plasticiser agent;
- and
- (d) 30% to 90% w/w of at least one volatile organic solvent,
- wherein said composition forms a flexible, porous and physiologically compatible skin patch when sprayed onto skin and is allowed to dry, wherein said patch disintegrates progressively over a 24–48 hour time period.
A non-aerosol sprayable skin patch composition consisting essentially of:
- (a) 0.01% to 10% w/w of at least one water-soluble physiologically active ingredient;
- (b) 1% to 50% w/w of polymethacrylic acid;
- (c) 0.1% to 20% w/w of polybutylphthalate;
- (d) 0% to 90% w/w of isopropanol;
- (e) 0% to 90% w/w of acetone;
- and
- (f) ethylacetate up to 100% w/w,
- wherein said composition forms a flexible, porous and physiologically compatible skin patch when sprayed onto skin and is allowed to dry, and wherein said patch disintegrates progressively over a 24–48 hour time period.
Dependencies are inferred from the claim text.