Modification of cyclooxygenase and lipoxygenase activity with asteridae extracts and optionally boswellic acid
AssigneeShaklee Corporation
InventorsPeter X. Zhang, Michael T. Yatcilla
Life of this patent
Estimating the term…
Abstract
Extracts from plants in the Asteridae subfamily, such as Carthamus tinctorious, are effective to selectively inhibit COX-2 activity and/or enhance COX-1 activity. When Asteridae extracts are combined with boswellic acid, the combination exhibits a synergistic inhibitory effect on both COX-2 and LO. Such extracts and combinations are used in methods of selectively inhibiting COX-2, inhibiting LO, and/or enhancing COX-1 activity as well as in the methods of treating conditions that would respond favorably to any of these effects.
Claims22
A composition comprising:
- an extract of Boswellia serrata;
- and
- an organic solvent/supercritical (OSSC) extract of Carthamus tinctorious;
- wherein the ratio of extract of Boswellia serrata to OSSC extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and OSSC extract of Carthamus tinctorious combined is 24 μg/ml.
A composition comprising:
- an extract of Boswellia serrata;
- and
- an OSSC extract of Carthamus tinctorious;
- wherein the ratio of extract of Boswellia serrata to OSSC extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and OSSC extract of Carthamus tinctorious combined is 20 μg/ml.
A composition comprising:
- an extract of Carthamus tinctorious wherein the extract of Carthamus tinctorious is a freeze-dried, powdered, ethanol extract from a flower of the Carthamus tinctorious plant that was extracted at about 45° C. or below;
- and
- an extract of Boswellia serrata wherein the extract of Boswellia serrata comprises about 6% 3-O-acetyl-11-keto-β-boswellic acid and about 64% total boswellic acid;
- wherein the ratio of extract of Boswellia serrata to extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and extract of Carthamus tinctorious combined is 24βg/ml.
A composition comprising:
- an extract of Carthamus tinctorious wherein the extract of Carthamus tinctorious is a freeze-dried, powdered, ethanol extract from a flower of the Carthamus tinctorious plant that was extracted at about 45° C. or below;
- and
- an extract of Boswellia serrata wherein the extract of Boswellia serrata comprises about 6% 3-O-acetyl-11-keto-β-boswellic acid and about 64% total boswellic acid;
- wherein the ratio of extract of Boswellia serrata to extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and extract of Carthamus tinctorious combined is 20 μg/ml.
A composition comprising:
- an extract of Carthamus tinctorious wherein the extract of Carthamus tinctorious is prepared by mixing whole Carthamus tinctorious flower petals with ethanol, filtering the ethanol from the flower petals, evaporating the ethanol at a temperature of about 35° C. to about 45° C. to obtain a first extract, combining the first extract with cornstarch to form a mixture of 85% extract and 15% cornstarch, freeze-drying the mixture, and powdering the mixture to obtain the extract of Carthamus tinctorious;
- and
- an extract of Boswellia serrata comprising about 6% 3-O-acetyl-11-keto-β-boswellic acid and about 64% total boswellic acid;
- wherein the ratio of extract of Boswellia serrata to extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and extract of Carthamus tinctorious combined is 24 pg/mI.
A composition comprising:
- an extract of Carthamus tinctorious wherein the extract of Carthamus tinctorious is prepared by mixing whole Carthamus tinctorious flower petals with ethanol, filtering the ethanol from the flower petals, evaporating the ethanol at a temperature of about 350° C. to about 450° C. to obtain a first extract, combining the first extract with cornstarch to form a mixture of 85% extract and 15% cornstarch, freeze-drying the mixture, and powdering the mixture to obtain the extract of Carthamus tinctorious;
- and
- an extract of Boswellia serrata comprising about 6% 3-O-acetyl-11-keto-β-boswellic acid and about 64% total boswellic acid;
- wherein the ratio of extract of Boswellia serrata to extract of Carthamus tinctorious is 1000:150 and the concentration of extract of Boswellia serrata and extract of Carthamus tinctorious combined is 20 μg/mI.
Dependencies are inferred from the claim text.