Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsMoshe Fleshner-Barak, E. Itzhak Lerner, Vered Rosenberger
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Abstract
The invention is directed to a drug delivery device for controlled release of a drug, comprising a core that has a cylindrical plug embedded therein; and a coating that at least partially surrounds the core. The core is comprised of a drug and excipients. The coating surrounding the core is essentially impermeable to the drug. The cylindrical plug, which is embedded in the core, may be hollow or solid. The drug delivery device enables zero-order drug release profiles as well as more complicated release profiles to be obtained. The invention is also directed to a method of making the drug delivery device.
Claims44
A drug delivery device, comprising:
- a core comprising a drug;
- a cylindrical plug embedded in the core, wherein said cylindrical plug comprises a swellable material;
- and
- a coating at least partially surrounding the core and covering the plug, wherein
- said coating is essentially impermeable to the drug, and said plug punctures
- said coating upon swelling of said plug, thereby forming an orifice in said coating.
A method of making a drug delivery device comprising:
- forming a core comprising a drug;
- embedding a cylindrical plug in the core, wherein said cylindrical plug comprises a swellable material;
- and
- at least partially coating the core and covering the plug with a coating which is essentially impermeable to the drug, wherein said plug punctures said coating upon swelling of said plug, thereby forming an orifice in said coating.
Dependencies are inferred from the claim text.