Atrial fibrillation therapy with pulmonary vein support
AssigneeSt. Jude Medical, Atrial Fibrillation Division, Inc.
InventorEric Falkenberg
Life of this patent
Estimating the term…
Abstract
A system and method for treatment of paroxysmal atrial fibrillation by destruction of conductive pathways between the pulmonary veins and the left atrium. A stent is delivered by catheter to the left atrium and to the ostium of a pulmonary vein to be treated. The stent is positioned in the pulmonary vein and is deployed to engage and support the pulmonary vein. The stent prevents stenosis of the pulmonary vein as a result of ablation of tissue. The ablation is produced by a coating of a biologically active material on the stent which destroys tissue or slows electrophyisiologic conduction through the tissue. Alternatively, ablation is performed using RF energy, cryoablation, laser energy, or other ablation techniques.
Claims16
A method of treating atrial fibrillation, the method comprising:
- accessing a left atrium with a therapeutic device;
- performing a therapy on contractile tissue in a transitional region between a pulmonary vein and the left atrium:
- deploying an expandable member to engage and support a wall of the pulmonary vein within the pulmonary vein, wherein the expandable member carries an ablation causing agent and wherein performing a therapy on contractile tissue comprises delivering the ablation causing agent via electroporation;
- and
- removing the therapeutic device while leaving the expandable member in engagement with the pulmonary vein to maintain patency of the pulmonary vein.
A device for treating atrial fibrillation, the device comprising:
- a stent sized to be delivered to a left atrium through a guide catheter and expandable to engage a wall of a pulmonary vein between an arrhythmiatic focus and the left atrium;
- and
- a stent delivery catheter for carrying and deploying the stent;
- wherein an ablation causing agent is carried by the stent, wherein the ablation causing agent is a biologically active material, and wherein the stent utilizes electroporation to deliver the ablation causing agent to the cells of the pulmonary vein engaged by the stent.
A method of treating a pulmonary vein to electrically isolate arrhythmiatic foci, the method comprising:
- delivering, to an ostium of the pulmonary vein, a stent which carries at least one biologically active material;
- and
- deploying the stent in the pulmonary vein at a position to maintain patency of the pulmonary vein;
- wherein the biologically active material is delivered to tissue of the pulmonary vein engaged by the stent by electroporation;
- and
- wherein the biologically active material is an ablation causing agent.
A method of treating atrial fibrillation, the method comprising:
- accessing a left atrium with a therapeutic device;
- performing a therapy on contractile tissue in a transitional region between a pulmonary vein and the left atrium;
- deploying en expandable member to engage and support a wall of the pulmonary vein within the pulmonary vein, wherein the expandable member carries an ablation causing agent and wherein performing a therapy on contractile tissue comprises delivering the ablation causing agent via iontophoresis;
- and
- removing the therapeutic device while leaving the expandable member in engagement with the pulmonary vein to maintain patency of the pulmonary vein.
A device for treating atrial fibrillation, the device comprising:
- a stent sized to be delivered to a left atrium through a guide catheter and expandable to engage a wall of a pulmonary vein between an arrhythmiatic focus and the left atrium;
- and
- a stent delivery catheter for carrying and deploying the stent;
- wherein an ablation causing agent is carried by the stent, wherein the ablation causing agent is a biologically active material, and wherein the stent utilizes iontophoresis to deliver the ablation causing agent to the cells of the pulmonary vein engaged by the stent.
A method of treating a pulmonary vein to electrically isolate arrhythmiatic foci, the method comprising:
- delivering, to an ostium of the pulmonary vein, a stent which carries at least one biologically active material;
- and
- deploying the stent in the pulmonary vein at a position to maintain patency of the pulmonary vein;
- wherein the biologically active material is delivered to tissue of the pulmonary vein engaged by the stent by iontophoresis;
- and
- wherein the biologically active material is an ablation causing agent.
Dependencies are inferred from the claim text.