US 7,192,445 B2 · Medical prosthetic devices and implants having improved biocompatibility

Abstract

Disclosed are medical prosthetic devices or medical implants which exhibit improved biocompatitibly. The devices or implants include a metal material, e.g. titanium, in which the metal surface parts are coated with a corresponding hydride material that contains one or more biomolecule substance. This biomolecule substance may contain one or more biologically active molecules, e.g. bio-adhesives, biopolymers, blood proteins, enzymes, extra cellular matrix proteins, extra cellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, enzyme inhibitors, drugs, biologically active anions and cations, vitamins, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), marker biomuolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.

Claims18

Dependent claims

A medical prosthetic device or medical implant comprising a metal material selected from the group consisting of titanium or an alloy thereof, zirconium or an alloy thereof, tantalum or an alloy thereof, hafnium or an alloy thereof, niobuim or an alloy thereof and a chromium-vanadium alloy,

wherein surface parts of the metal material comprise a layer of a corresponding hydride material selected from the group consisting of titanium hydride, zirconium hydride, tantalum hydride, hafnium hydride, niobium hydride, chromium hydride, vanadium hydride, and chromium-vanadium hydride,
wherein the layer of hydride material comprises one or more biomolecule substances, said biomolecule substance being an ampholyte.

wherein surface parts of the metal material comprise a layer of a corresponding hydride material selected from the group consisting of titanium hydride, zirconium hydride, tantalum hydride, hafnium hydride, niobium hydride, chromium hydride, vanadium hydride, and chromium-vanadium hydride, and
wherein the layer of hydride material comprises one or more biomolecule substances, said biomolecule substance exhibiting a net positive charge dissolved in a salt solution having an ionic strength within the range of from 0.01 to 10 M, a temperature within the range of from 20 to 100° C., and a pH within the range of from 0 to 10.

Dependencies are inferred from the claim text.

Medical prosthetic devices and implants having improved biocompatibility

Life of this patent

Medical prosthetic devices and implants having improved biocompatibility

Life of this patent

Abstract

Claims18