Patient specific circulation model
AssigneeUniversity of Illinois, Board of Trustees
InventorsFady T. Charbel, Marlyn E. Clark, Lewis Sadler, Noam Alperin, Francis Loth, Meide Zhao
Life of this patent
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Abstract
A method and apparatus are provided for modeling circulation in a living subject. The method includes the steps of developing a model for living subjects in general and correcting the model to substantially conform to the overall cerebral physiology of the living subject. The method further includes the step of calculating a cerebral flow of the living subject based upon the corrected model and a selected cerebral blood flow perturbation.
Claims30
A method of modeling circulation in a living subject, such method comprising the steps of:
- simulating the fluid dynamics of an arterial network, wherein the simulation models blood flow through a plurality of arterial segments including one or more terminal efferent vessels;
- adapting the simulation to substantially conform to a specific arterial anatomy of the living subject;
- forcing the simulation with a forcing function made up of one or more flow-time or pressure-time signatures;
- calculating a blood flows in the arterial network based upon the forced simulation;
- measuring a blood flow in the living subject;
- correcting the simulation based on the measured and calculated blood flows;
- modifying the simulation to model a particular interventional procedure;
- and,
- calculating a post-procedure blood flow in a selected arterial segment using the modified simulation in order to predict an outcome of the actual interventional procedure performed in the living subject.
Apparatus for modeling circulation within a living subject, such apparatus comprising:
- a computerized model of an arterial network made up of a plurality of arterial segments including one or more terminal efferent vessels, wherein the apparatus includes means for calculating blood flows in the arterial network when the model is forced with a forcing function;
- means for adapting the model of the arterial network to substantially conform to a specific arterial anatomy of the living subject;
- means for measuring a blood flow in the living subject;
- means for correcting the model based upon the calculated and measured flows;
- means for modifying the model to reflect a particular interventional procedure;
- and,
- means for calculating a post-procedure blood flow in a selected arterial segment using the modified model in order to predict an outcome of the actual interventional procedure performed in the living subject.
A system for modeling circulation within a living subject, comprising:
- a computerized model of an arterial network made up of a plurality of arterial segments including one or more terminal efferent vessels, wherein the system includes means for calculating blood flows in the arterial network when the model is forced with a forcing function;
- means for adapting the model of the arterial network to substantially conform to a specific arterial anatomy of the living subject;
- wherein the arterial network is divided into a plurality of sectors, wherein each sector is terminated by a terminal efferent vessel and has a primary input vessel, and further wherein the terminal efferent vessels are modeled as terminal efferent resistances;
- means for measuring blood flows in the living subject corresponding to the primary input flows of the sectors;
- and
- means for adjusting the terminal efferent resistances for each sector in a manner which tends to make the calculated flow in the terminal efferent vessel match the measured primary input flow for each such sector.
Dependencies are inferred from the claim text.