Supplemented and unsupplemented tissue sealants, methods of their production and use

A method of preparing a fibrin sealant bandage comprising layering

• (i) a backing layer, having at least one tissue-facing surface;
• and
• (ii) a hemostatic component layer on said at least one tissue-facing surface of said backing layer, said hemostatic component layer comprising a hemostatically effective amount of fibrinogen;
• wherein said hemostatic component layer contains no added fibrinolysis inhibitor;
• wherein said backing layer contains no collagen;
• and
• wherein said fibrinogen is effective to form a fibrin clot that covers and adheres to tissue of a patient when said bandage is applied to said tissue.

A bandage for treating tissue of a patient, said bandage comprising:

• (i) a backing;
• and
• (ii) a physiologically-acceptable adhesive layer on the tissue-facing surface of the backing;
• and
• (iii) a layer of materials comprising a hemostatically effective amount of fibrinogen wherein said fibrinogen is effective to form a fibrin matrix in the presence of thrombin, Ca++ and a hydrating agent;
• wherein the layer of materials contains no added fibrinolysis inhibitor;
• wherein said backing layer contains no collagen;
• and wherein the layer of materials is adhesively affixed to the tissue-facing surface of the adhesive layer.

A method of using a bandage for treating tissue of a patient, said method comprising applying said bandage to said tissue, said bandage comprising:

• (i) a backing;
• and
• (ii) a physiologically-acceptable adhesive layer on the tissue-facing surface of the backing;
• and
• (iii) a layer of materials comprising a hemostatically effective amount of fibrinogen wherein said fibrinogen is effective to form a fibrin matrix in the presence of thrombin, Ca++ and hydrating agent;
• wherein the layer of materials contains no added fibrinolysis inhibitor;
• wherein said backing layer contains no collagen;
• and wherein the layer of materials is adhesively affixed to the tissue-facing surface of the adhesive layer.

A bandage for treating tissue of a patient, said bandage comprising:

• (i) a backing;
• and
• (ii) a layer of dry materials comprising a hemostatically effective amount of fibrinogen;
• wherein said layer of dry materials contains no fibrinolysis inhibitor and wherein said layer of dry materials is adhesively affixed to said backing;
• wherein said backing contains no collagen;
• and
• wherein said fibrinogen is effective to form a fibrin matrix in the presence of thrombin, Ca++ and a hydrating agent.

A bandage for treating tissue of a patient, wherein said bandage is produced by a process comprising:

• (i) providing a backing layer having at least one tissue-facing surface;
• and
• (ii) layering a hemostatic component on at least one tissue-facing surface of said backing layer, said component layer comprising a hemostatically effective amount of fibrinogen;
• wherein said hemostatic component layer contains no added fibrinolysis inhibitor;
• wherein said backing layer contains no collagen;
• and
• wherein said fibrinogen is effective to form a fibrin clot that covers and adheres to tissue of a patient when said bandage is applied to said tissue.

A bandage for treating tissue of a patient, wherein said bandage is produced by a process comprising:

• (i) providing a backing;
• (ii) layering a physiologically-acceptable adhesive on the tissue-facing surface of said backing;
• and
• (iii) adhesively affixing a layer of material to the tissue-facing surface of the adhesive layer,
• wherein said layer of materials comprises a hemostatically effective amount of fibrinogen;
• wherein said layer of materials contains no added fibrinolysis inhibitor;
• wherein said backing layer contains no collagen;
• and
• wherein said fibrinogen is effective to form a fibrin matrix in the presence of thrombin, Ca++ and a hydrating agent.

A bandage for treating tissue of a patient, wherein said bandage is produced by a process comprising:

• (i) providing a backing;
• and
• (ii) adhesively affixing a layer of dry material to said backing, wherein said dry material comprises a hemostatically effective amount of fibrinogen;
• wherein said fibrinogen is effective to form a fibrin matrix in the presence of thrombin, Ca++ and a hydrating agent;
• wherein said backing contains no collagen;
• and wherein said dry material contains no added fibrinolysis inhibitor.