Magnetically guidable carriers and methods for the targeted magnetic delivery of substances in the body
AssigneeStereotaxis, Inc.
InventorsJonathan Harburn, Rogers C. Ritter
Life of this patent
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Abstract
A method of delivering a substance to targeted tissue comprising the steps of: delivering a plurality of magnetically responsive particles which are carrying the substance and have a hydrophobic coating into the patient's vasculature upstream of the targeted tissue; and applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.
Claims24
A method of delivering a substance to targeted tissue comprising the steps of:
- delivering a plurality of magnetically responsive particles which are carrying the substance and have a hydrophobic coating into the patient's vasculature upstream of the targeted tissue, wherein the particles include a less hydrophobic layer under the hydrophobic layer, wherein the hydrophobic layer is at least partially removable;
- and further comprising the step of at least partially removing the hydrophobic layer after the particles are at the delivery site to facilitate the release of the substance;
- and
- applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.
A method of delivering a substance to a targeted tissue comprising the steps of:
- delivering a plurality of magnetically responsive particles which are carrying the substance and having a hydropgobic coating into the patient's vasculature upstream of the targeted tissue, wherein particles include a hydrophilic layer under the hydrophobic layer, wherein the hydrophobic layer is at least partially removable;
- and further comprising the step of at least partially removing the hydrophobic layer after the particles are at the delivery site to facilitate the release of the substance;
- and
- applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.
A magnetically guided carrier composition for carrying a substance, the composition comprising a plurality of particles, each comprising a magnetically responsive core, surrounded by a outer hydrophobic layer that is at least partially removable, and an inner hydrophilic layer.
Dependencies are inferred from the claim text.