Production of humanised antibodies to TNFα
AssigneeUCB Celltech
InventorsDiljeet Singh Athwal, Derek Thomas Brown, Andrew Neil Charles Weir, Andrew George Popplewell, Andrew Paul Chapman, David John King
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Abstract
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
Claims12
An isolated DNA sequence which encodes the heavy chain of an antibody molecule, wherein said antibody molecule has specificity for TNFα and further wherein the variable domain of said heavy chain comprises the CDR having the sequence given in SEQ ID NO:1 for CDRH1, a CDR having the sequence given in SEQ ID NO:2 or SEQ ID NO:7 for CDRH2, and the CDR having the sequence given in SEQ ID NO:3 for CDRH3.
An isolated DNA sequence which encodes the light chain of an antibody molecule, wherein said antibody molecule has specificity for TNFα and further wherein the variable domain of said light chain comprises the CDR having the sequence given in SEQ ID NO:4 for CDRL1, the CDR having the sequence given in SEQ ID NO:5 for CDRL2, and the CDR having the sequence given in SEQ ID NO:6 for CDRL3.
An isolated DNA sequence comprising the sequence shown in SEQ ID NO:
- 125, 127 or 129.
Dependencies are inferred from the claim text.