Acylated arylcycloalkylamines and their use as pharmaceuticals

A compound of the formula I,

• wherein:
• R1 is aryl, which is optionally substituted one or more times by C1–C6-alkyl, halogen, CF3, C1–C6-alkoxy, C1–C6-alkylmercapto, —CN, COOR10, CONR11R12, NR13R14, S(O)mR15 or S(O)2NR16R17;
• R2 is oxazolyl, thiazolyl, or pyrrolyl, each of which is optionally substituted one or more times by:
• halogen, —CN, —NH2, C3–C5-alkandiyl, phenyl, heteroaryl, aryl-substituted C1–C4-alkyl, heteroaryl-substituted C1–C4-alkyl, —CF3, —NO2, —OH, phenoxy, benzyloxy, (C1–C10-alkyl)-COO—, —S(O)mR20, —SH, phenylamino, benzylamino, (C1–C10-alkyl)-CONH—, (C1–C10-alkyl)-CO—N(C1–C4-alkyl)-, phenyl-CONH—, phenyl-CO—N(C1–C4-alkyl)-, heteroaryl-CONH—, heteroaryl-CO—N(C1–C4-alkyl)-, (C1–C10-alkyl)-CO—, phenyl-CO—, heteroaryl-CO—, CF3—CO—, —OCH2O—, —OCF2O—, —OCH2CH2O—, —CH2CH2O—, —COOR21, —CONR22R23, —C(NH)—NH2, —SO2NR24R25, R26SO2NH—, R27SO2N(C1–C6-alkyl)-,
• optionally substituted C1–C10-alkyl, optionally substituted C2–C10-alkenyl, optionally substituted C2–C10-alkynyl, optionally substituted C1–C10-alkoxy, optionally substituted C1–C10-alkylamino, optionally substituted di(C1–C10-alkyl)amino, wherein the optional substituents of the optionally substituted substituents are selected from one or more of the group consisting of F, OH, C1–C8-alkoxy, aryloxy, C1–C8-alkylmercapto, NH2, C1–C8-alkylamino and di(C1–C8-alkyl)amino, or
• a residue of a saturated or partially unsaturated aliphatic monocyclic 5- to 7-membered heterocycle containing 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S, wherein the heterocycle is optionally substituted one or more times by halogen, C1–C3-alkyl, C1–C3-alkoxy, OH, oxo or CF3, and wherein the heterocycle is optionally condensed to the aryl group or heteroaryl group representing R2, and
• wherein for each oxazolyl, thiazolyl or pyrrolyl as R2 bearing an aryl, heteroaryl, phenyl, aryl-containing, heteroaryl-containing or phenyl-containing group as an optional substituent, that each aryl, heteroaryl, phenyl, aryl-containing, heteroaryl-containing and phenyl-containing group is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, OH, C1–C3-alkoxy or CF3;
• R10 is H, C1–C6-alkyl or benzyl, wherein the phenyl group of the benzyl is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy or CF3;
• R11 is H, C1–C6-alkyl, which is optionally substituted by phenyl, phenyl, indanyl or heteroaryl, wherein each phenyl, indanyl and heteroaryl is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy or CF3;
• R12 is H or C1–C6-alkyl;
• R13 is H, C1–C6-alkyl,
• optionally substituted phenyl, optionally substituted benzyl, optionally substituted heteroaryl, optionally substituted phenyl-CO—, or optionally substituted heteroaryl-CO—, wherein the optional substituents of the optionally substituted substituents are selected from one or more of the group consisting of halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy and CF3;
• R14 is H or C1–C6-alkyl;
• R15 is C1–C6-alkyl, CF3,
• optionally substituted phenyl or optionally substituted heteroaryl, wherein the optional substituents of the optionally substituted substituents are selected from one or more of the group consisting of halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy and CF3;
• R16 is H, C1–C6-alkyl, which is optionally substituted by phenyl, phenyl, indanyl or heteroaryl, wherein each phenyl, indanyl, and heteroaryl is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy or CF3;
• R17 is H or C1–C6-alkyl;
• R20 is C1–C10-alkyl, which is optionally substituted one or more times by F, OH, C1–C8-alkoxy, aryloxy, C1–C8-alkylmercapto, C1–C8-alkylamino, or di(C1–C8-alkyl)amino, CF3,
• optionally substituted phenyl or optionally substituted heteroaryl, wherein the optional substituents of the optionally substituted phenyl and heteroaryl are selected from one or more of the group consisting of halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy and CF3;
• R21 is H,
• C1–C10-alkyl, which is optionally substituted one or more times by F, C1–C8-alkoxy or di(C1–C8-alkyl)amino,
• aryl-(C1–C4-alkyl)- or heteroaryl-(C1–C4-alkyl)-, wherein each of the aryl-(C1–C4-alkyl)- or heteroaryl-(C1–C4-alkyl)- is optionally substituted one or more times by halogen, C1–C4-alkyl, C1–C4-alkoxy or di(C1–C6-alkyl)amino;
• R22 is H, C1–C10-alkyl, which is optionally substituted one or more times by F, C1–C8-alkoxy, di(C1–C8-alkyl)amino or phenyl,
• phenyl, indanyl or heteroaryl, wherein each phenyl, indanyl and heteroaryl is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy or CF3;
• R23 is H or C1–C10-alkyl;
• R24 is H, C1–C10-alkyl, which is optionally substituted one or more times by F, C1–C8-alkoxy, di(C1–C8-alkyl)amino or phenyl,
• phenyl, indanyl or heteroaryl, wherein each phenyl, indanyl and heteroaryl is optionally substituted one or more times by halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy or CF3;
• R25 is H or C1–C10-alkyl;
• R26 is C1–C10-alkyl, which is optionally substituted one or more times by F, OH, C1–C8-alkoxy, aryloxy, C1–C8-alkylmercapto, C1–C8-alkylamino, or di(C1–C8-alkyl)amino,
• CF3,
• optionally substituted phenyl or optionally substituted heteroaryl, wherein the optional substituents of the optionally substituted phenyl and heteroaryl are selected from one or more of the group consisting of halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy and CF3;
• R27 is C1–C10-alkyl, which is optionally substituted one or more times by F, OH, C1–C8-alkoxy, aryloxy, C1–C8-alkylmercapto, C1–C8-alkylamino, or di(C1–C8-alkyl)amino,
• CF3,
• optionally substituted phenyl or optionally substituted heteroaryl, wherein the optional substituents of the optionally substituted phenyl and heteroaryl are selected from one or more of the group consisting of halogen, —CN, C1–C3-alkyl, C1–C3-alkoxy and CF3;
• wherein heteroaryl is a residue of a 5-membered to 10-membered, aromatic, monocyclic or bicyclic heterocycle containing one or more heteroatoms selected from the group consisting of N, O and S;
• wherein aryl is phenyl, naphth-1-yl or naphth-2-yl;
• m is 0, 1 or 2;
• and
• n is 1, or 3;
• or a stereoisomer or a mixture of stereoisomers in any ratio of the compound, or a pharmaceutically acceptable salt of the compound, stereoisomer or mixture of stereoisomers of the compound.