Methods of producing neurons

A method of producing neurons, the method comprising:

• incubating a population of mammalian cells in a plasma clot containing about 6 mM to about 18 mM Ca2+,
• wherein the mammalian cells are:
• (i) human or rat cells;
• and (ii) skin cells, fat tissue cells, or bone marrow cells, and
• wherein the incubation is carried out in a culture medium comprising one or more additives selected from the group consisting of B27 supplement, epidermal growth factor, R3 long form insulin-like growth factor, basic fibroblast growth factor, and leukemia inhibitory factor, wherein during the incubation neurons appear in the plasma clot.