Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, Weidong Xiao
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Abstract
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
Claims13
A recombinant vector comprising a 5′ AAV-1 inverted terminal repeat (ITR) and a heterologous nucleic acid for delivery to a cell, wherein said ITR has the sequence consisting of:
- nt 1 to 143 of SEQ ID NO:
- 1.
A recombinant vector comprising a 3′ AAV-1 inverted terminal repeat (ITR) and a heterologous nucleic acid for delivery to a cell, wherein said ITR has the sequence of:
- nt 4576 to 4718 of SEQ ID NO:
- 1.
A composition comprising a recombinant virus having an AAV-1 capsid comprising an AAV-1 protein selected from among AAV-1 vp1 having the amino acid sequence of SEQ ID No:
- 13;
- AAV-1 vp2 having the amino acid sequence of SEQ ID NO:
- 15 and AAV-1 vp3 having the amino acid sequence of SEQ ID NO:
- 17 and a heterologous molecule which comprises an AAV 5′ inverted terminal repeat sequence (ITR), a transgene, and an AAV 3′ ITR.
Dependencies are inferred from the claim text.