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US 7,183,072 B1Granted
Kit for detecting Her-2/neu gene by site-specific metal deposition
AssigneeNanoprobes, Inc.
InventorJames F. Hainfeld
Life of this patent
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Abstract
Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is also described. These methods enable a wide range of applications including sensitive detection of genes and proteins, use as probes for microscopy, nanofabrication, biosensors, and remediation.
Claims6
A kit for detecting Her-2/neu gene or protein in a test sample, comprising:
- metal ions selected from the group consisting of silver, gold, iron, mercury, nickel, copper, platinum, palladium, cobalt, iridium ions and a mixture thereof;
- an oxidizing agent;
- a reducing agent;
- an enzyme;
- and a binding moiety that binds to Her-2/neu gene or protein in the test sample.
2 more elements
Dependencies are inferred from the claim text.