Stable topical drug delivery compositions
AssigneeNicholas V. Perricone
InventorsNicholas V. Perricone, Chim Potini
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Abstract
A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
Claims19
A carrier composition for transdermal delivery of a macromolecule, comprising a polyenylphosphatidylcholine-enriched phosphatidyicholine component entrapping said macromolecule for transdermal delivery to dermal vasculature, wherein said phosphatidyicholine component stabilizes said macromolecule at room temperature and wherein said polyenylphosphatidylcholine-enriched phosphatidylcholine component further comprises a polyglycol having molecular weight of 200 and a polyglycol having molecular weight of 400.
A stable topical insulin composition, comprising:
- carrier having a polyenylphosphatidylcholine-enriched phosphatidyicholine component, said polyenylphosphatidylcholine-enriched phosphatidylcholine component including a polyglycol having molecular weight of 200 and a polyglycol having molecular weight of 400, and
- insulin entrapped within said carrier for transdermal delivery of the insulin to dermal vasculature.
Dependencies are inferred from the claim text.