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US 7,181,266 B2Granted
Materials and methods for near-infrared and infrared lymph node mapping
AssigneesMassachusetts Institute of Technology, Beth Isreal Deaconess Medical Center, Inc.
InventorsJohn V. Frangioni, Moungi G. Bawendi, Sungjee Kim, Yong Taik Lim
Life of this patent
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Abstract
A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the near infrared.
Claims24
A method of imaging a lymphatic system of an animal comprising:
- introducing at an injection site a composition subcutaneously in the animal, the composition including a particle including a semiconductor nanocrystal;
- exciting the particle with an excitation light source;
- and
- detecting emission from the particle.
1 more element
A method of imaging a lymphatic system of an animal comprising:
- introducing at an injection site a composition subcutaneously in the animal, the composition including a particle including a semiconductor nanocrystal, wherein the nanocrystal includes a core of a first semiconductor material and an overcoating of a second semiconductor material on the core wherein the first semiconductor material and the second semiconductor material are selected so that, upon excitation, one carrier is substantially confined to the core and the other carrier is substantially confined to the overcoating;
- exciting the particle with an excitation light source;
- detecting emission from the particle;
- and
- generating a real-time image of an area surrounding the injection site.
2 more elements
Dependencies are inferred from the claim text.