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US 7,179,790 B2Granted
Brain natriuretic peptide
AssigneeScios, Inc.
InventorsJ. Jeffrey Seilhamer, John A. Lewicki, Robert M. Scarborough, J. Gordon Porter
Life of this patent
Estimating the term…
Abstract
Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis.
Claims1
A method to synthesize a peptide of the formula Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cis-Lys-Val-Leu-Arg-Arg-His (SEQ ID NO:
- 49) or the amide thereof which method comprises
- sequentially adding amino acids from the carboxy terminal and using an α-amino protected amino acid using solid phase peptide synthesis.
Dependencies are inferred from the claim text.