Use of parvovirus for brain tumor therapy
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsJean Rommelaere, Jan Cornelis, Christiane Dinsart, Jorg R. Schlehofer, Karsten Geletneky, Marta Herrero Y Calle
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Abstract
Treatment of brain tumors by a composition including parvovirus, e.g., parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. Also described is the use of a parvovirus for the preparation of a pharmaceutical composition for the treatment of a brain tumor. Tumors for which the compositions and methods of the invention have particular utility include glioma, medulloblastoma and meningioma.
Claims9
A method of treating a brain tumor in a patient, said method comprising administering to said patient an amount of parvovirus H1 that is tumoricidally effective against said brain tumor, wherein said parvovirus H1 is administered to the patient by intratumoral administration.
A method of treating a brain tumor in a patient, said method comprising administering to said patient an amount of parvovirus H1 that is tumoricidally effective against said brain tumor, wherein said parvovirus H1 is administered to said patient by injection into the brain tumor and said injection is targeted by neuronavigation.
A method of treating a brain tumor in a patient, said method comprising administering to said patient an amount of parvovirus H1 that is tumoricidally effective against said brain tumor, wherein said parvovirus H1 is administered to said patient by implantation in said patient of at least one wafer impregnated with the parvovirus H1, and the implantation comprises implantation in a tumoral cavity formed by surgical removal of tumor tissue.
Dependencies are inferred from the claim text.