Resonant sensor and sensing system
AssigneeBioScale, Inc.
InventorsEd Crawley, Mark Lundstrom, Brett Masters, Alok Srivastava, Martin Schmidt, Michael Miller
Life of this patent
Estimating the term…
Abstract
The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.
Claims40
A sensor chip including a substrate, a plurality of anchors, a plurality of tethers, and a moving member coupled to the substrate and disposed for movement relative to the substrate, wherein the anchors are fixed relative to the substrate and the tethers are connected to the anchors and the moving member, the moving member having an oscillatory motion in a first direction and an oscillatory motion in a second direction in response to movement of the substrate, the first direction being different than the second direction, the moving member including a plurality of receptors, the receptors being configured for selectively binding to a first measurand.
A method of determining a property of a sample, comprising:
- A. providing a sensing chip, the sensing chip including a substrate, a plurality of anchors, a plurality of tethers, and a resonant sensor, the resonant sensor including a moving member disposed for movement relative to the substrate, wherein the anchors are fixed reletive to the substrate and the tethers are connected to the anchors and the moving member;
- B. exposing the sensing chip to a sample;
- C. moving the substrate;
- D. monitoring an oscillatory movement, relative to the substrate, of the moving member in a first direction;
- and
- E. monitoring an oscillatory movement, relative to the substrate, of the moving member in a second direction, the second direction being different than the first direction.
A method of determining a property of a sample, comprising:
- A. providing a first sensing chip, the first sensing chip including a first substrate, a pluarlity of anchors, a plurality of tethers, and a first resonant sensor, the first resonant sensor including a first moving member disposed for movement relative to the first substrate, wherein the anchors are fixed relative to the substrate and the tethers are connected to the anchors and the moving member;
- B. measuring a response of the first moving member to a first environment, including the steps of:
- 1. exposing the first sensing chip to a first environment;
- 2. moving the first substrate;
- 3. monitoring an oscillatory movement of the first moving member in a first direction;
- and;
- 4. monitoring an oscillatory movement of the first moving member in a second direction, the second direction being different than the first direction;
- C. providing a second sensing chip, the second sensing chip including a second substrate, a plurality of anchors, a plurality of tethers, and a second resonant sensor, the second resonant sensor including a second moving member disposed for movement relative to the second substrate, wherein the anchors are fixed relative to the substrate and the tethers are connected to the anchors and the moving member;
- D. measuring a response of the second moving member to a second environment, the second environment being different than the first environment, including the steps of:
- 1. exposing the second sensing chip to a second environment;
- 2. moving the second substrate;
- 3. monitoring an oscillatory movement of the second moving member in the first direction;
- and;
- 4. monitoring an oscillatory movement of the moving member in the second direction;
- E. comparing the measured responses of the first and second moving members.
A method of determining a property of a sample, comprising:
- A. providing a sensing chip, the sensing chip including a substrate, a plurality of anchors, a plurality of tethers, and a resonant sensor, the resonant sensor including a moving member disposed for movement relative to the substrate, wherein the anchors are fixed relative to the substrate and the tethers are connected to the anchors and the moving member;
- B. measuring a response of the moving member to a first environment, including the steps of:
- 1. exposing the sensing chip to a first environment;
- 2. moving the substrate;
- 3. monitoring an oscillatory movement of the moving member in a first direction;
- and;
- 4. monitoring an oscillatory movement of the moving member in a second direction, the second direction being different than the first direction;
- C. measuring a response of the moving member to a second environment, the second environment being different than the first environment, including the steps of:
- 1. exposing the sensing chip to a second environment;
- 2. moving the substrate;
- 3. monitoring an oscillatory movement of the moving member in the first direction;
- and;
- 4. monitoring an oscillatory movement of the moving member in the second direction;
- D. comparing the measured responses of the moving member in response to the first and second environments.
A sensing system comprising:
- A. a sensor chip, the sensor chip including a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate, the moving member moving in an oscillatory manner relative to the substrate in a first direction and in an oscillatory manner in a second direction in response to movement of the substrate, the first direction being different than the second direction;
- B. an optical system, the optical system generating an output signal representative of movement of the moving member in the first direction and of movement of the moving member in the second direction.
A sensing system comprising:
- A. a sensing chip, the sensing chip including a substrate and a resonant sensor, the resonant sensor including a moving member and a connector, the connector coupling the moving member to the substrate, the moving member being disposed for movement relative to the substrate, the moving member oscillating, relative to the substrate, in a first direction and oscillating, relative to the substrate, in a second direction in response to movement of the substrate;
- B. an optical system, the optical system generating an output signal representative of a frequency of oscillation of the moving member in the first direction and of a frequency of oscillation of the moving member in the second direction.
A sensing system comprising:
- A. a sensing chip, the sensing chip including a substrate and a plurality of resonant sensors, each of the resonant sensors including a moving member disposed for movement relative to the substrate, the moving member of each of the sensors oscillating, relative to the substrate, in a first direction and oscillating, relative to the substrate, in a second direction in response to movement of the substrate;
- B. an optical system, the optical system generating an output signal representative of a frequency of oscillation of each of the moving members in the first direction and of a frequency of oscillation of each of the moving members in the second direction.
A sensor chip including a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate, the moving member having an oscillatory motion in a first direction and an oscillatory motion in a second direction in response to movement of the substrate, the first direction being different than the second direction, the moving member including a plurality of receptors, the receptors being configured for selectively binding to a first measurand, wherein the sensor chip also includes an optical grating disposed on the moving member and an optical grating disposed on the substrate, the optical gratings permitting measurement of the position of the moving member relative to the substrate in the first and second directions.
A method of determining a property of a sample, comprising:
- A. providing a sensing chip, the sensing chip including a substrate and a resonant sensor, the resonant sensor including a moving member disposed for movement relative to the substrate, wherein the sensing chip also includes an optical grating disposed on the moving member and an optical grating disposed on the substrate;
- B. exposing the sensing chip to a sample;
- C. moving the substrate;
- D. monitoring an oscillatory movement with the optical gratings, relative to the substrate, of the moving member in a first direction;
- and
- E. monitoring an oscillatory movement with the optical gratings, relative to the substrate, of the moving member in a second direction, the second direction being different than the first direction.
Dependencies are inferred from the claim text.