US 7,176,242 B2Granted

N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives

AssigneesElan Pharmaceuticals, Inc., Pharmacia & Upjohn Company

InventorsVarghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom

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Abstract

Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

Claims20

Dependent claims

A compound of the formula

or a pharmaceutically acceptable salt thereof wherein R1 is:
(I) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, C3–C8 cycloalkyl (optionally substituted with C1–C3 alkyl C1–C3 alkoxy), —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, —NR1-aR1-b, and —OC═O—NR1-aR1-b, where R1-a and R1-b are independently at each occurence-H or C1–C6 alkyl,
(II) —CH2—S(O)0-2—(C1–C6 alkyl),
(III) —CH2CH2—S(O)0-2—(C1–C6 alkyl)
(IV) C2–C6 alkenyl with one or two double bonds, optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —tOH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b where R1-a and R1-b are —H or C1–C6 alkyl,
(V) C2–C6 alkynyl with one or two triple bonds, optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b where R1-a and R1-b are —H or C1–C6 alkyl, or
(VI) —(CH2)n1—(R1-aryl) where n1 is zero or one and where R1-aryl is phenyl, naphthyl, indanyl, indenyl, dihydronaphthyl, or tetralinyl each of which is optionally substituted with one, two, three, four, or five substituents selected from the group consisting of:
(A) C1–C6 alkyl optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —NR1-aR1-b, —C≡N, —CF3, and C1–C3 alkoxy,
(B) C2–C6 alkenyl optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(C) C2–C6 alkynyl optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(D) —F, Cl, —Br and —I,
(E) —C1–C6 haloalkoxy
(F) —C1–C6 alkoxy
(G) —NRN-2RN-3,
(H) —OH,
(I) —C≡N,
(J) C3–C7 cycloalkyl, optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(K) —CO—(C1–C4 alkyl),
(L) —SO2NR1-aR1-b,
(M) —CO—NR1-aR1-b, and
(N) —SO2—(C1–C4 alkyl),
where R2 is selected from the group consisting of:
(I) —H,
(II) C1–C6 alkyl, optionally substituted with one, two or three substituents independently selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1C3 alkoxy, and —NR1-aR1-b,
(IV) C2–C6 alkenyl with one or two double bonds, optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1C3 alkoxy, and —NR1-aR1-b, and
(V) C2–C6 alkynyl optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
where R3 is selected from the group consisting of:
(I) —H,
(II) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(IV) C2–C6 alkenyl, and
(V) C2–C6 alkynyl;
or R2 and R3 are taken together with the carbon to which they are attached to form a carbocycle of three, four, five, six, and seven carbon atoms,
RN is:
(I) RN-1—XN— where XN is —CO—,
where RN-1 is
(A) RN-aryl wherein RN-aryl at each occurrence is independently phenyl;
naphthyl;
tetralinyl;
indanyl;
indenyl;
dihydronaphthyl;
or 6,7,8,9-tetrahydro-5H-benzo[a]cycloheptenyl;
each of which is optionally substituted with 1, 2, or 3 groups that at each occurrence are independently selected from the group consisting of:
(1) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b, wherein R1-a and R1-b at each occurrence are independently H or C1–C6 alkyl,
(2) —OH,
(3) —NO2,
(4) —F, —Cl, —Br, —I,
(5) —CO2H,
(6) —C≡N,
(7) —(CH2)0-4—CO—NRN-2RN-3 wherein at each occurence RN-2 and RN-3 are the same or different and are selected from the group consisting of:
(a) —H,
(b) —C1–C8 alkyl optionally substituted with one substituent selected from the group consisting of:
(i) OH,
(ii) —NR′R″, and
(iii) phenyl,
(c) —C1–C8 alkyl optionally substituted with 1, 2, or 3 groups that are independently —F, —Cl, —Br, or —I,
(d) —C3–C8 cycloalkyl,
(e) —(C1–C2 alkyl)-(C3–C8 cycloalkyl),
(f) —(C1–C6 alkyl)-O—(C1–C3 alkyl),
(g) —C2–C6 alkenyl,
(h) —C2–C6 alkynyl,
(i) —C1–C6 alkyl chain with one double bond and one triple bond, and
(j) —R1-aryl, and
(8) —(CR′R″)0-4C—OR′;
(C) RN-aryl—W—RN-aryl,
where W is
(1) —(CH2)1-4—,
(2) —O—,
(3) —S(O)0-2—,
(4) —N(RN-5)—,
(5) —CO—;
or
(6) a bond;
where Rc is:
(I) —C1–C10 alkyl optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C6 alkoxy, —O-phenyl, —NR1-aR1-b, —OC═O NR1-aR1-b, —S(═O)0-2R1-a, —NR1-aC═O NR1-aR1-b, —C═O NR1-aR1-b, and —S(═O)2 NR1-aR1-b,
(II) —(CH2)0-3—(C3–C8) cycloalkyl where cycloalkyl can be optionally substituted with one, two or three substituents independently selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C6 alkoxy, —O-phenyl, —CO2H, —CO2—(C1–C4 alkyl), and —NR1-aR1-b,
(III) —(CRc-xR-y)0-4—RC-aryl at each occurrence is independently phenyl;
naphthyl;
tetralinyl;
indanyl;
indenyl;
dihydronaphthyl;
or 6,7,8,9-tetrahydro-5H-benzo[a]cycloheptenyl;
each of which is optionally substituted with 1, 2, or 3 groups that at each occurrence are independently selected from the group consisting of:
(1) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(2) —OH,
(3) —NO2,
(4) —F, —Cl, —Br, —I,
(5) —CO2H,
(6) —C≡N, and
(7) —(CH2)0-4—CO—NRN-2RN-3;
where Rc-x and Rc-y are independently selected from the group consisting of:
—H,
C1–C4 alkyl optionally substituted with one or two —OH,
C1–C4 alkoxy optionally substituted with 1, 2, or 3 —F,
—(CH2)0-4—C3–C8 cycloalkyl,
C2–C6 alkenyl,
C2–C6 alkynyl, and
phenyl,
or Rc-x and Rc-y are taken together with the carbon to which they are attached to form a carbocycle of three, four, five, six and seven carbon atoms;
(V) —(CRc-xRc-y)0-4Rc-aryl-RC-aryl,
and
R25 is hydrogen or C1–C6 alkyl.

100 more elements

A compound of the formula

or a pharmaceutically acceptable salt thereof, wherein R30 is selected from the group consisting of phenyl, dihydronaphthalenonyl dihydronaphthyl, and tetrahydronaphthyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of
C1–C10 alkyl optionally substituted with 1 phenyl or 1 CN;
OH, hydroxy C1–C10 alkyl optionally substituted with phenyl or (C1–C4 alkyl)phenyl, C1–C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl;
haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1–C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1–C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33;
—(C1–C6 alkyl)-SO2—(C1–C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1–C4 alkoxy, or R33;
—SO2—(C1–C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1–C4 alkoxy, —SO2—N(C1–C6 alkyl) (C1–C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33;
—SO2—NH(C1–C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1–C4 alkoxy or halogen, —(C1–C6 alkyl)-O-phenyl, —(C1–C6 alkyl)-O—(C1–C6 alkyl)-phenyl, halogen, —NHC(O)NH2, —NHC(O)NH(C1–C6 alkyl), —NHC(O)N(C1–C6 alkyl)(C1–C6 alkyl), —N(C1–C6 alkyl)C(O)NH2, —N(C1–C6 alkyl)C(O)NH(C1–C6 alkyl), —N(C1–C6 alkyl)C(O)N(C1–C6 alkyl) (C1–C6 alkyl), —S—(C1–C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, NHC(S)NH2, —NHC(S)NH(C1–C6 alkyl), —NHC(S)N(C1–C6 alkyl) (C1–C6 alkyl), —CO2(C1–C6 alkyl), phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br;
—C2–C4 alkynyl-phenyl, —O—C3–C8 cycloalkyl, —O—(C1–C6 alkyl)-R33;
—C(O)—(C1–C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1–C6 alkyl), or N(C1–C6 alkyl)(C1–C6 alkyl);
—C(O)NH-phenyl, —C(O)N(C1–C6 alkyl)-phenyl, —S—(C1–C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently CN or OH;
(C1–C6 thioalkoxy)-(C1–C6 alkyl), C2–C8 alkynyl, —(CH2)0-4—SO2—(C1–C10 alkyl) wherein the alkyl group is optionally substituted with OH;
—NHC(O)NH(C3–C8 cycloalkyl), —N(C1–C6 alkyl)C(O)NH(C3–C8 cycloalkyl), —N(C1–C6 alkyl)C(O)N(C1–C6 alkyl)(C3–C8 cycloalkyl), —NHC(O)N(C1–C6 alkyl)(C3–C8 cycloalkyl), —(C1–C6 alkoxy)-(C1–C6 thioalkoxy);
—CO2—(C1–C6 alkyl) wherein the alkyl group is optionally substituted with phenyl;
wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1–C8 alkyl, C2–C8 alkenyl, hydroxy C1–C6 alkyl, C1–C6 haloalkyl, C1C6 alkoxy C1–C6 alkyl, —(CH2)0-4—SO2—(C1–C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms;
—(C1–C6 alkyl)-C(O)NH2, —(C1–C6 alkyl)—C(O)NH(C1–C6 alkyl), —(C1–C6 alkyl)-C(O)N(C1–C6 alkyl)(C1–C6 alkyl), —(C1–C6 alkyl)-NH2, —(C1–C6 alkyl)-NH(C1–C6 alkyl), —(C1–C6 alkyl)-N(C1–C6 alkyl)(C1–C6 alkyl), —(C1–C6 alkyl)phenyl cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1–C6 alkyl), —(C1–C6 thioalkoxy)-(C1–C6 alkyl), —C(O)—(C1–C6 alkyl), (C1–C6 alkoxy), —(C2–C6 alkenyloxy), and —(C1–C6 alkyl)-CO2—(C1–C6 alkyl), wherein
the phenyl groups are unsubstituted or substituted with 1, 2, 3, 4,or 5 groups that are independently C1–C4 alkyl, hydroxy, C1–C4 alkoxy, halogen,
R33 at each occurrence is independently, H, NH2, NH(C1–C6 alkyl), N(C1–C6 alkyl)(C1–C6 alkyl), N(C1–C6 alkyl)(phenyl), N(C1–C6 alkyl)(benzyl);
R35 is phenyl, C3–C8 cycloalkyl, —S-phenyl, C1–C6 alkyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1–C4 alkyl, C1–C4 alkoxy, OH, hydroxy C1–C6 alkyl, halogen, halo C1–C6 alkyl, halo C1–C6 alkoxy, —O—(C1–C6 alkyl)-phenyl, —CO2—(C1–C6 alkyl), —(C1–C4 alkyl)-(C5–C6 cycloalkyl), or (CH2)0-4CN;
R40 is phenyl, biphenyl, —(C1–C4 alkyl)-O—C(O)NH-phenyl wherein the pheriyl is optionally substituted with 1, 2, or 3 halogen atoms;
—(C1–C4 alkyl)-O—C(O)N(C1–C6 alkyl)-phenyl, —(C1–C6 alkyl)-phenyl, —(C1–C4 alkyl)-SO2NH2, —(C1–C4 alkyl)-SO2NH(C1–C6 alkyl), —(C1–C4 alkyl)-SO2N(C1–C6 alkyl)(C1–C6 alkyl), —SO2NH2, —SO2NH(C1–C6 alkyl), —SO2N(C1–C6 alkyl)(C1–C6 alkyl), CN, —(CH2)0-4—(C3–C8 cycloalkyl), —(C1–C4 alkyl)-C(O)O—(C1–C4 alkyl), —(C1–C4 alkyl)-R33, C1–C10 alkyl, C2–C8 alkenyl, —(C1–C4 alkyl)—NHC(O)—(C1–C4 alkyl), —(CH2)0-4—C(O)NH2, —(CH2)0-4—C(O)NH(C1–C6 alkyl), —(CH2)0-4—C(O)N(C1–C6 alkyl)(C1–C6 alkyl), naphthyl, tetrahydronaphthyl, dihydronaphthyl, alkoxyalkyl, -phenyl-cyclohexyl, -phenyl-cyclopentyl, -phenyl-(C1–C6 alkyl)-cyclopentyl, -phenyl-(C1–C6 alkyl)-cyclohexyl, 7-oxa-bicyclo[2.2.1]heptyl;
-phenyl-bicyclo[2.2.1]heptyl;
bicyclo[2.2.1]heptyl;
phenyl-C(O)-phenyl;
-phenyl-O-phenyl;
-phenyl-O-benzyl;
wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1–C8 alkyl optionally substituted with 1 or two groups that are independently CN or OH;
C1–C6 alkoxy, halo (C1–C8 alkyl), halo (C1–C4 alkoxy), —O—(C1–C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, CN, —CHO, C1–C4 thioalkoxy, —NHSO2—(C1–C6 alkyl), —N(C1–C4 alkyl)SO2—(C1–C4 alkyl) wherein the alkyl groups are optionally substituted with 1, 2,or 3 halogens;
OH;
—SO2R33;
R33;
C2–C8 alkynyl;
C2–C8 alkenyl;
thioalkoxyalkyl;
—SO2—(C1–C10 alkyl);
—NR31R32;
—C(O)—NR31R32;
—OC(O)R33;
C1–C8 alkanoyl;
and —(C1–C6 alkyl)-C(O)—(C1–C6 alkoxy), —C(O)—(C1–C6 alkoxy);
—O—(C1–C6 alkyl)-C(O)NR31R32;
—CO2—(C1–C6 alkyl);
R41a and R41 are independently H, cyclohexyl, phenyl, or C1–C6 alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, C1–C4 thioalkoxy, C1–C4 thioalkoxy C1–C6 alkyl;
or —C1–C6 alkyl-SO2—C1–C6 alkyl;
R40, R41, and the atom to which they are attached form a C3–C8 cycloalkyl ring which is optionally substituted with C1–C4 alkyl, C1–C4 alkoxy, halogen, —CO2NH2, —CO2NH(C1–C6 alkyl), or —CO2N(C1–C6 alkyl)(C1–C6 alkyl);
or phenyl which is optionally substituted with 1, 2,or 3 groups that are independently halogen or C1–C6 alkyl;
and
R42 is H.

44 more elements

A compound which is

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′, N′-dipropyl-isophthalamide;
N-[1-(3,5-Difluoro-benzyl)-3-(1-ethylcarbamoyl-ethylamino)-2-hydroxy-propyl]-5-methyl-N′, N′-dipropyl-isophthalamide;
N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N′-dimethylcarbamoylmethyl-5,N′-dimethyl-isophthalamide;
N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-methylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
N-[3-(1-Benzylcarbamoyl-ethylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropylisophthalamide;
N-[3-(1-Carbamoyl-3-methyl-butylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
N-[3-(1-Carbamoyl-ethylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzoylamino)-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
5-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-hydroxy-benzamide;
N-[3-(3-Cyclohexyl-1-phenyl-propylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;
N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-hydroxy-3,5-dimethoxy-benzamide;
4-Acetyl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;
N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-hydroxy-3,5-dimethyl-benzamide;
4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2,6-dimethyl-benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
methyl[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]methylcarbamate;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-propylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N3,N3-dipropylisophthalamide;
5-bromo-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isobutylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N1-butyl-N3-{-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
N1,N1-dibutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-hydroxyprop-1-ynyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-sec-butylbenzyl)amino]1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-(cyclopropylmethyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
5-(aminosulfony)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(}3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopentylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(1,1′-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N1N1-diallyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3-propylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-propylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diethyl-5-methylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfinyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]propanamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutyl-N3,5-dimethylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydro-3-[(3-pyridin-2-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl -N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(3-phenyipropanoyl)-3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl -N3,N3-dipropylisophthalamide;
N1-(sec-butyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-(2-phenylethyl)isophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-prop-2-ynylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3,5-dimethylisophthalamide;
3-({[(2R,3S)4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl dimethylcarbamate;
N1-benzyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
N1-(sec-butyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;
1-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diisobutyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl -N3,N3-dipropylisophthalamide;
methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenylcarbamate;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutyl-5-methylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-isopropyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopropyl-N3,5-dimethylisophthalamide;
N1-allyl-N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopropyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide;
N1-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[2-(dimethylamino)ethyl]-N3-ethyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diisopropyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)amino]benzamide;
N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-ethyl-5-methylisophthalamide;
2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;
N1-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methylbenzamide;
N1-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(ethylthio(ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[benzyl(cyanomethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
methyl N-[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}lamino)-2-hydroxybutyl]-beta-alaninate;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
2-{[(benzyloxy)carbonyl]amino}-7-[(cyclopropylmethyl)amino]-1,2,4,5,7-pentadeoxy-5-(3,5-difluorobenzyl)-1-[(1-propylbutyl)sulfonyl]-D-threo-hept-3-ulose trifluoroacetate;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
3-[({1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-1-phenylethyl)amino]propyl}amino)sulfonyl]N,N-dipropylbenzamide;
5-bromo-N1-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3ethoxypropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3,3-dimethylbutyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,3diphenyipropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)propyl]amino}propyl)-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-thiazol-2-yl)benzamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(phenyl)amino]propyl}amino)propyl]-5-methyl -N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2-hydroxypropyl}-3-{[(2-hydroxyethyl)amino]sulfonyl}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3-dihydroxypropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2S)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-methylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxyethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{methyl[(trifluoromethyl)sulfonyl]amino}benzamide;
N1-[(1S,2R)-3-[(1,3-dicyclohexylpropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1-ethylpropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3dimethylcyclohexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(2-{4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1(hydroxymethyl )propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3,5-dichloroberizyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenoxybenzamide;
4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)propyl]amino}propyl)-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-(trifluoromethoxy)benzamide;
3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(2,5-dimethylbenzoyl)-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(ethylthio)benzamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(cycloheptylamino)-1-(3,5difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1R,2S)-1-(hydroxymethyl)-2-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(phenoxymethyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(3-methoxybenzoyl)-5-methylbenzamide;
N1-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
methyl 4-{(2R,3R)-2-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-3-hydroxy-4-[(3-methoxybenzyl)amino]butyl}benzoate;
N1-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
2-{[(2R,3S)-4-(3,5-difluorophenyl-3-({3[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 3-methoxyphenylcarbamate;
3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluorornethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-({[2-(methylamino)ethyl]amino}sulfonyl)benzamide;
N-(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(4-methylbenzoyl)benzamide;
N1-[(1S,2R)-3-({2-[4-(aminosulfonyl)phenyl]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-oxo-2-(propylamino)ethyl]benzamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(2-methylbenzoyl)benzamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-propoxybenzamide;
N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methoxy-4-oxobutanamide;
N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl -N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-((1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-hydroxy-4-{[(methylamino)carbonothioyl]amino}benzamide;
N-((1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;
N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-glycylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)methyl]benzamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[tert-butyl(cyclohexyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{(3-(dimethylamino)-2,2-dimethylpropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(diisopropylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)propyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[2-(acetylamino)ethyl]amino}-1-(3,5difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[4-(1-cyanocyclopentyl)phenyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-({4-[4-(acetylamino)phenoxy]phenyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(4-benzoyl-2,3-dimethylphenyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(2-amino-2-oxo-1-phenylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-[3,5-bis(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;
2-chloro-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxybenzamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[4-(diethylamino)-1-methylbutyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxy-1,1-dimethylethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
3,5-bis(acetylamino)-N-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzamide;
4-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino}-2-hydroxypropyl}-N2,N2-dimethylphthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(4-methylphenyl)sulfonyl]glycinamide;
4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-(aminosulfonyl)-4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2-hydroxypropyl}benzamide;
4-{[(cyclobutylcarbonyl)amino]methyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;
N1-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
3-chloro-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl)amino}propyl}benzamide;
3-chloro-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl}benzamide;
3-chloro-N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
N-((1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-chlorobenzamide;
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-chlorobenzamide;
3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino]propyl}benzamide;
3-{[(3-chlorobenzyl)amino]sulfonyl}-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl}benzamide;
3-{[(3-chlorobenzyl)amino]suifonyl}-N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;
N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl -N3,N3-dipropylisophthalamide;
N1-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-((3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S)1-{(1R)-1-hydroxy2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyi]but-3-ynyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexyimethyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-((1S)-1-{(1R)-1-hydroxy-2-[(3methoxybenzyl)amino}ethyl}-3-methylbutyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-5-methyl -N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S)-1-{(1R)-1-hydroxy-2((3-methoxybenzyl)amino]ethyl}but-3-ynyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-5-methyl -N3,N3-dipropylisophthalamide;
N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-5-methyl -N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[1-methyl-1-(methylsulfonyl)ethyl]benzamide;
N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4methoxybenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[l-methyl-1-(methylsulfonyl)ethyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(ethylsulfonyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-(propylsulfonyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pentylsulfonyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)sulfonyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)sulfonyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)sulfonyl]benzamide;
N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5fluorobenzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;
N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
3-chloro-N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[(3-(trifluoromethyl)benzyl]amino}propyl}benzamide;
4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;
4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
5-bromo-N1-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,7-dimethoxy-1-oxoindane-2-carboxamide;
N′-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;
N1-[(1S,2R)-3-[(2-{4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-morpholin-4-ylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide;
N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(benzyloxy)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethoxy-5-methylisophthalamide;
N1-(allyloxy)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutoxy-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-(2,2,3,3,3-pentafluoropropyl)isophthalamide;
ethyl 4-({3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}amino)butanoate;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-bis (2,2,2-trifluoroethyl)isophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2,2,3,3,4,4,4-heptafluorobutyl)-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[2-(4-methylpentanoyl)hydrazino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
5-bromo-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)amino]benzamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-[(methylsulfonyl)amino]-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropyl-5-{[(trifluoromethyl)sulfonyl]amino}isophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]aminosulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;
5-{[bis (2-hydroxyethyl) amino]sulfonyl}-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;
5-(aminosulfonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3-propylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalammide;
N1-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethyl-1-hydroxybutyl)benzammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
N1{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N3,N 3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
5-bromo-N1-((1S,2R)-1-[3-fluoro-4-(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalammide;
5-bromo-N1-((1S,2R)-2-hydroxy-1-(2,3,4-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalammide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)-5-methylbenzamide hydrochloride;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-methoxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(2-propylpentanoyl)benzamide hydrochloride;
N1-(sec-butyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
N1-allyl-N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1,N1-dibutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diisobutyl-5-methylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl -N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-(1-(3,5-difluorobenzyl)-3-{[2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide;
N1-[(1S,2R)-3-[(1,1′-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-ethyl-5-methylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalammide;
N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N 3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N3,N3-dipropylisophthalamide;
methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[dimethylamino(sulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)(oxo)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3, N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-butylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pentylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pent-4-enylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-cyclopentylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-[(3-cyclohexylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(cyclohexylmethyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-hex-5-enylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
methyl (2S)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate;
N1-[(1S,2R)-3-{[3-(4-chlorobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(3-cyanopropyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(4-cyanobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-{[3-(6-cyanohexyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl) amino]propyl}-N1,5-dimethylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{methyl[(trifluoromethyl)sulfonyl]amino}-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[methyl(methylsulfonyl)amino]-N3,N3-dipropylisophthalamide;
N1-butyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-N1,5-dimethylisophthalamide;
N1-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
5-bromo-N1-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-cyclobutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-pentylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopentyl-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-(2-hydroxyethyl)-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-ethoxyethyl)-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-methoxyethyl)-N3,5-dimethylisophthalamide;
N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-pentylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-hydroxyethyl)-5-methyl-N3-propylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-(2-methoxyethyl)-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-(2-methylcyclohexyl)isophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-methoxyethyl)-5-methyl-N3-propylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-bis(2-methoxyethyl)-5-methylisophthalamide;
N1-allyl-N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipentylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-bis(2-ethoxyethyl)-5-methylisophthalamide;
N1-butyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-N1,5-dimethylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)sulfonyl]-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2R)-2-hydroxypropyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(2-methylpentanoyl)benzamide hydrochloride;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)amino]-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2S)-2-hydroxypropyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
N-[(1S,2R)-3-(butylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-(ethylthio)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzamide;
3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-acetyl-N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[ethyl(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;
5-bromo-N1-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide hydrochlormide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N3,N3-dipropylisophthalamide hydrochlormide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;
N-{(1R,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyrylbenzamide;
hydrochloride;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-propylpentanoyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide hydrochloride;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1S)-2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3 N3-dipropylisophthalamide;
N′-[(1S,2R)-3-{[(1S)-2-(benzylamino)-1-methyl-2-oxoethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-({2-[bis(2-hydroxyethyl)amino]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
or a pharmaceutically acceptable salt thereof.

533 more elements

A compound which is:

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;
5-bromo-N1-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
5-[(tert-butylamino)sulfonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
5-{[tert-butyl(methyl)amino]sulfonyl}-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[ethyl(methyl)amino]sulfonyl}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N3,N3-dipropylisophthalamide;
methyl 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]benzoate;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide;
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide (1:1);
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethylbenzamide;
N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(ethoxymethyl)benzamide;
3-[(tert-butylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(ethylamino)sulfonyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylamino)sulfonyl]benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-ethoxybenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)carbonothioyl]benzamide;
3-[(E)-(cyanoimino)(dipropylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-propylbutoxy)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[2-(dimethylamino)ethyl]-N3, 5-dimethylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylbutanoyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-methylpentanoyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-[(1S)-1-methylpropyl]isophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-[(1R)-1-methylpropyl]isophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-pentylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylhexyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1′-biphenyl-3-carboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′-(methylthio)-1,1′-biphenyl-3-carboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-fluorobenzyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-fluorobenzyl)benzamide;
ethyl 3′-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1,1′-biphenyl-2-carboxylate;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′,5′-difluoro-1,1′-biphenyl-3-carboxamide;
tert-butyl 4-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]benzylcarbamate;
3-(5-chloropentyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-phenylethyl)benzamide trifluoroacetate;
3-(cyclohexylmethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-cyclopentyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hex-5-enylbenzamide;
3-(6-cyanohexyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
5-(diethylamino)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(dimethylamino)-N3,N3-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[ethyl(propyl)amino]methyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-methyl-5-{[methyl(propyl)amino]methyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-[(dipropylamino)methyl]-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(3-methoxypropyl)benzamide;
5-amino-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
3-[(cyclohexylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
3-[({(1S,2R)-1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoic acid;
5-[(diethylamino)methyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)methyl]-N3,N3-dipropylisophthalamide;
3-{[benzyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide;
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide (1:1);
formic acid compound with 4-{[(4-chlorophenyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with 4-{[benzyl(phenyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with 4-{[(2-cyanoethyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with 4-{[cyclohexyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-pyridin-2-ylethyl)amino]sulfonyl}benzamide (2:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(phenyl)amino]sulfonyl}benzamide (1:1);
formic acid compound with 4-{[benzyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-phenylethyl)amino]sulfonyl}benzamide (1:1);
formic acid compound with 4-{[allyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with 4-{[[2-(diethylamino)ethyl](methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (2:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(propyl)amino]sulfonyl}benzamide (1:1);
formic acid compound with 4-{[butyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(pentyl)amino]sulfonyl}benzamide (1:1);
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[isopentyl(methyl)amino]sulfonyl}benzamide (1:1);
N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-(2-methoxyethyl)benzamide;
3-{[cyclohexyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
3-bicyclo[2.2.1]hept-2-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-(butylamino)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-methylbenzamide;
formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dipropylamino)sulfonyl]benzamide (1:1);
formic acid compound with 4-[(diethylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methylbenzamide;
3-bromo-5-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-methylbenzamide;
3-{[butyl(methyl)amino]methyl}-5-cyano-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzamide;
3-{[[2-(diethylamino)ethyl](methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-2-methoxyacetamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoindane-5-carboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyindane-5-carboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[isobutyl(methyl)amino]methyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[methyl(pentyl)amino]methyl}benzamide;
3-bromo-5-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
3-[(butylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-5-methylbenzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethyl-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)prop-1-ynyl]-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N3,N3-dipropylisophthalamide;
5-(3-aminopropyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)propyl]-N3,N3-dipropylisophthalamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)prop-1-ynyl]-N3,N3-dipropylisophthalamide;
5-(3-aminoprop-1-ynyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
3-(allylsulfonyl)-N-((1S,2R)-1(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
3-(allylthio)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)but-1-ynyl]-N3,N3-dipropylisophthalamide;
N-((1S,2R)-1(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)butyl]-N3,N3-dipropylisophthalamide;
3-(allylsulfinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N3,N3-dipropylisophthalamide;
or pharmaceutically acceptable salts thereof.

126 more elements

A compound which is:

N′-[(1S,2S)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;
N′-[(1S,2R)-1(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1E)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;
N′-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylamino)propyl]-5-methyl-N,N-dipropylisophthalamide;
N′-((1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-oxo-1-methyl-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-[(1S,2R)-3-{[(1S)-1-benzyl-2-oxo-2-(methylamino)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[oxo(methylamino)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-oxo-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
N′-[(1S,2R)-3-({(1S)-1-[amino(oxo)methyl]-3-methylbutyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
N′-[(1S,2R)-3-[(2-amino-2-oxo-1-methylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
tert-butyl [(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl][3-(ethylthio)benzyl]carbamate;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-hexyl-N,5-dimethylisophthalamide;
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzoyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;
N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-fluoro-1-naphthamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-{(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-5-methylbenzamide;
4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dimethylbenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-3,5-dimethoxybenzamide;
4-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxybenzamide;
4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2,N2-dimethylphthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;
5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxybenzamide;
N′-[(1S,2R)-3-{[(1R)-3-cyclohexyl-1-phenylpropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;
N-cyclohexyl-N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide;
N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)-2-oxoethyl]-N,5-dimethylisophthalamide
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)ethyl]-N-ethyl-5-methylisophthalamide
N-benzyl-N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide
N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethyl-N-(2-phenylethyl)isophthalamide
N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1-phenylvinyl)benzyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide
N′-[(1S,2R)-3-[(3-bicyclo[2.2.1]hept-2-ylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide
ethyl 3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]propanoate
ethyl 4-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]butanoate
methyl(2R)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate
ethyl3′-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)biphenyl-2-carboxylate
or a pharmacuetically acceptable salt thereof.

51 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/291,318Filed 8 Nov 2002 · us provisional application
Priority: 8 Nov 2001
Published: US 2004/0171881 A12 Sep 2004
Granted: 13 Feb 2007
Term ends: Not estimatedThe source records don’t support an estimate.

Classification123 codes

C07D 263/32
Having two or three double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07C 233/36
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…

Family

Application60/337,122Us provisional application · filed 8 Nov 2001
Application60/344,086Us provisional application · filed 28 Dec 2001
Application60/345,635Us provisional application · filed 3 Jan 2002
US 2004/0171881 A1Pre-grant publication · published 2 Sep 2004
US 7,176,242 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A compound of the formula

or a pharmaceutically acceptable salt thereof wherein R1 is:
(I) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, C3–C8 cycloalkyl (optionally substituted with C1–C3 alkyl C1–C3 alkoxy), —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, —NR1-aR1-b, and —OC═O—NR1-aR1-b, where R1-a and R1-b are independently at each occurence-H or C1–C6 alkyl,
(II) —CH2—S(O)0-2—(C1–C6 alkyl),
(III) —CH2CH2—S(O)0-2—(C1–C6 alkyl)
(IV) C2–C6 alkenyl with one or two double bonds, optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —tOH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b where R1-a and R1-b are —H or C1–C6 alkyl,
(V) C2–C6 alkynyl with one or two triple bonds, optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b where R1-a and R1-b are —H or C1–C6 alkyl, or
(VI) —(CH2)n1—(R1-aryl) where n1 is zero or one and where R1-aryl is phenyl, naphthyl, indanyl, indenyl, dihydronaphthyl, or tetralinyl each of which is optionally substituted with one, two, three, four, or five substituents selected from the group consisting of:
(A) C1–C6 alkyl optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —NR1-aR1-b, —C≡N, —CF3, and C1–C3 alkoxy,
(B) C2–C6 alkenyl optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(C) C2–C6 alkynyl optionally substituted with one, two or three substituents selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(D) —F, Cl, —Br and —I,
(E) —C1–C6 haloalkoxy
(F) —C1–C6 alkoxy
(G) —NRN-2RN-3,
(H) —OH,
(I) —C≡N,
(J) C3–C7 cycloalkyl, optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(K) —CO—(C1–C4 alkyl),
(L) —SO2NR1-aR1-b,
(M) —CO—NR1-aR1-b, and
(N) —SO2—(C1–C4 alkyl),
where R2 is selected from the group consisting of:
(I) —H,
(II) C1–C6 alkyl, optionally substituted with one, two or three substituents independently selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1C3 alkoxy, and —NR1-aR1-b,
(IV) C2–C6 alkenyl with one or two double bonds, optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1C3 alkoxy, and —NR1-aR1-b, and
(V) C2–C6 alkynyl optionally substituted with one, two or three substituents independently selected from the group consisting of —F, —Cl, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
where R3 is selected from the group consisting of:
(I) —H,
(II) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(IV) C2–C6 alkenyl, and
(V) C2–C6 alkynyl;
or R2 and R3 are taken together with the carbon to which they are attached to form a carbocycle of three, four, five, six, and seven carbon atoms,
RN is:
(I) RN-1—XN— where XN is —CO—,
where RN-1 is
(A) RN-aryl wherein RN-aryl at each occurrence is independently phenyl;
naphthyl;
tetralinyl;
indanyl;
indenyl;
dihydronaphthyl;
or 6,7,8,9-tetrahydro-5H-benzo[a]cycloheptenyl;
each of which is optionally substituted with 1, 2, or 3 groups that at each occurrence are independently selected from the group consisting of:
(1) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b, wherein R1-a and R1-b at each occurrence are independently H or C1–C6 alkyl,
(2) —OH,
(3) —NO2,
(4) —F, —Cl, —Br, —I,
(5) —CO2H,
(6) —C≡N,
(7) —(CH2)0-4—CO—NRN-2RN-3 wherein at each occurence RN-2 and RN-3 are the same or different and are selected from the group consisting of:
(a) —H,
(b) —C1–C8 alkyl optionally substituted with one substituent selected from the group consisting of:
(i) OH,
(ii) —NR′R″, and
(iii) phenyl,
(c) —C1–C8 alkyl optionally substituted with 1, 2, or 3 groups that are independently —F, —Cl, —Br, or —I,
(d) —C3–C8 cycloalkyl,
(e) —(C1–C2 alkyl)-(C3–C8 cycloalkyl),
(f) —(C1–C6 alkyl)-O—(C1–C3 alkyl),
(g) —C2–C6 alkenyl,
(h) —C2–C6 alkynyl,
(i) —C1–C6 alkyl chain with one double bond and one triple bond, and
(j) —R1-aryl, and
(8) —(CR′R″)0-4C—OR′;
(C) RN-aryl—W—RN-aryl,
where W is
(1) —(CH2)1-4—,
(2) —O—,
(3) —S(O)0-2—,
(4) —N(RN-5)—,
(5) —CO—;
or
(6) a bond;
where Rc is:
(I) —C1–C10 alkyl optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C6 alkoxy, —O-phenyl, —NR1-aR1-b, —OC═O NR1-aR1-b, —S(═O)0-2R1-a, —NR1-aC═O NR1-aR1-b, —C═O NR1-aR1-b, and —S(═O)2 NR1-aR1-b,
(II) —(CH2)0-3—(C3–C8) cycloalkyl where cycloalkyl can be optionally substituted with one, two or three substituents independently selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C6 alkoxy, —O-phenyl, —CO2H, —CO2—(C1–C4 alkyl), and —NR1-aR1-b,
(III) —(CRc-xR-y)0-4—RC-aryl at each occurrence is independently phenyl;
naphthyl;
tetralinyl;
indanyl;
indenyl;
dihydronaphthyl;
or 6,7,8,9-tetrahydro-5H-benzo[a]cycloheptenyl;
each of which is optionally substituted with 1, 2, or 3 groups that at each occurrence are independently selected from the group consisting of:
(1) C1–C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C1–C3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —C≡N, —CF3, C1–C3 alkoxy, and —NR1-aR1-b,
(2) —OH,
(3) —NO2,
(4) —F, —Cl, —Br, —I,
(5) —CO2H,
(6) —C≡N, and
(7) —(CH2)0-4—CO—NRN-2RN-3;
where Rc-x and Rc-y are independently selected from the group consisting of:
—H,
C1–C4 alkyl optionally substituted with one or two —OH,
C1–C4 alkoxy optionally substituted with 1, 2, or 3 —F,
—(CH2)0-4—C3–C8 cycloalkyl,
C2–C6 alkenyl,
C2–C6 alkynyl, and
phenyl,
or Rc-x and Rc-y are taken together with the carbon to which they are attached to form a carbocycle of three, four, five, six and seven carbon atoms;
(V) —(CRc-xRc-y)0-4Rc-aryl-RC-aryl,
and
R25 is hydrogen or C1–C6 alkyl.

100 more elements

Facts

Application

10/291,318Filed 8 Nov 2002 · us provisional application

Priority

8 Nov 2001

Published

US 2004/0171881 A12 Sep 2004

Granted

13 Feb 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification123 codes

C07D 263/32
Having two or three double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07C 233/36
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…

Family

Application60/337,122Us provisional application · filed 8 Nov 2001

Application60/344,086Us provisional application · filed 28 Dec 2001

Application60/345,635Us provisional application · filed 3 Jan 2002

US 2004/0171881 A1Pre-grant publication · published 2 Sep 2004

US 7,176,242 B2This patent

From the US filing history. Foreign family members aren’t listed.