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US 7,176,188 B2Granted
Method of lethally sensitizing human and animal cells
AssigneeUniversitéLaval
InventorSerge Desnoyers
Life of this patent
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Abstract
The present invention relates to a method, nucleic acid and amino acid sequences to sensitizing human or animal cells to be killed by chemical entities or irradiation. Particularly, the present invention describes nucleic acid and amino acid sequences pertaining to the group of PME factors, that are target to sensitizing the cells before treatment with killing elements.
Claims7
A method for killing human cells or animal cells comprising the steps of:
- a) inhibiting the expression of a polynucleotide encoding the polypeptide sequence of SEQ ID NO:
- 9 in human cells or animal cells thereby causing the sensitization of said cells;
- b) treating cells sensitized in step a) with a dose of a chemical entity or irradiation effective to kill said cells.
Dependencies are inferred from the claim text.