Rescue agents for treating botulinum toxin intoxications
AssigneeAllergan, Inc.
InventorsShengwen Li, Kei Roger Aoki, Lance E. Steward, Joseph Francis
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Abstract
The present invention relates to rescue agents for use in the treatments of toxin intoxication—for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or from accidental overdose in the course of treatment. In some embodiments, the rescue agents comprise at least one of an inactive botulinum toxin and a modified nontoxic nonhemagglutinin. The present invention also provides for glycosylated active and inactive toxins and methods of using same.
Claims16
A method of treating a botulinum toxin intoxication in a mammal, the method comprising the step of administering to the mammal an effective amount of a glycosylated inactive botulinum toxin, wherein the effective amount of the glycosylated inactive botulinum toxin is an amount of glycosylated inactive botulinum toxin sufficient to compete with an active botulinum toxin for:
- (a) binding to a cell surface receptor,
- (b) translocation through an endosomal membrane,
- (c) binding to the cleavage site of a SNAP-25 protein,
- (d) binding to the cleavage of a synaptobrevin (VAMP), or
- (e) binding to the cleavage site of a syntaxin,
- wherein the glycosylated inactive botulinum toxin has a mutated light chain,
- thereby reducing the ability of the active botulinum toxin to intoxicate a neuron.
Dependencies are inferred from the claim text.