Methods, computer program products, and devices for calibrating chronically tissue implanted sensors using chronically tissue
AssigneesSicel Technologies, Inc., North Carolina State University
InventorsCharles W. Scarantino, H. Troy Nagle, Chang-Soo Kim, Stefan Ufer, Jason Fiering, Bahram Ghaffarzadeh Kermani
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Abstract
Calibration of in vivo oxygen and pH sensor systems can be performed by generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode and determining a level of the constituent element in the tissue via the in vivo sensor electrode. Accordingly, accurate monitoring of tissue can be achieved while reducing the need to calibrate the in vivo sensor systems using invasive procedures. Related electrode assemblies are also discussed.
Claims44
A method for calibrating an in vivo sensor system, the method comprising the steps of:
- generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode;
- and
- determining a level of the constituent element in the tissue via the in vivo sensor electrode, wherein the step of generating comprises the steps of:
- generating a first constituent element at a first time at the in vivo generating electrode;
- and
- generating a second constituent element at a second time at the in vivo generating electrode.
A method for calibrating an in vivo sensor system, the method comprising the steps of:
- generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode;
- determining a level of the constituent element in the tissue via the in vivo sensor electrode, wherein the step of generating comprises the steps of:
- generating a first constituent element at a first time at the in vivo generating electrode, wherein the step of generating the first constituent element comprises the step of conducting a current from a first in vivo generating electrode to a second in vivo generating electrode through the tissue;
- generating a second constituent element at a second time at the in vivo generating electrode;
- and
- wherein the step of generating the second constituent element comprises the step of conducting the current from the second in vivo generating electrode to the first in vivo generating electrode through the tissue.
A method for calibrating an in vivo sensor system, the method comprising the steps of:
- generating a first constituent element of an environment proximate to an in vivo sensor electrode at an in vivo generating electrode;
- determining a first level of the first constituent element via the in vivo sensor electrode;
- generating a second constituent element of the environment proximate to the in vivo sensor electrode at the in vivo generating electrode;
- and
- determining a second level of the second constituent element using an in vivo sensor electrode.
A method for calibrating an in vivo sensor system the method comprising the steps of:
- generating a first constituent element of an environment proximate to an in vivo sensor electrode at a first in vivo generating electrode, wherein the step of generating the first constituent element comprises the step of conducting a current from the first in vivo generating electrode to a second in vivo generating electrode;
- determining a first level of the first constituent element via the in vivo sensor electrode;
- generating a second constituent element of the environment proximate to the in vivo sensor electrode at the in vivo generating electrode;
- and
- determining a second level of the second constituent element using an in vivo sensor electrode, wherein the step of generating the second constituent element comprises the step of conducting a current from the second in vivo generating electrode to the first in vivo generating electrode.
A method for calibrating an in vivo sensor system, the method comprising the steps of:
- generating a changing H+/OH− ion level proximate to an in vivo sensor electrode;
- determining a rate of change of a voltage at the in vivo sensor electrode generated in response to the changing H+/OH− ion level;
- and
- determining a rate of change of the voltage associated with the changing H+/OH− ion level.
A computer program product for calibrating a sensor system adapted for in vivo use, the computer program product comprising:
- a computer readable storage medium having computer-readable program code embodied in said medium, said computer-readable program code comprising:
- computer-readable program code for generating a constituent element of an environment proximate to a sensor electrode adapted for in vivo use via a generating electrode adapted for in vivo use;
- and
- computer-readable program code for determining a level of the constituent element in the tissue using the sensor electrode, wherein the computer-readable program code for generating comprises:
- computer-readable program code for generating a first constituent element at a first time at the generating electrode;
- and
- computer-readable program code for generating a second constituent element at a second time at the generating electrode.
Dependencies are inferred from the claim text.