Mammals expressing IGF-1 and alpha-lactalbumin in their milk
AssigneeThe Board of Trustees of the University of Illinois
InventorsMatthew B. Wheeler, Sharon M. Donovan, Gregory T. Bleck, Marcia Monaco-Siegel
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Abstract
The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. The present invention thus provides a method of facilitating piglet development and decreasing piglet mortality.
Claims6
A transgenic non-human mammal having a genome, said genome comprising a heterologous nucleic acid sequence encoding a growth factor and encoding alpha-lactalbumin operably linked to a mammary preferential promoter, wherein descendants of said transgenic mammal express an increased amount of growth factor in their milk and an increased amount of alpha-lactalbumin in their milk as compared to control non-transgenic mammals.
A transgenic non-human mammal having a genome, said genome comprising a heterologous nucleic acid sequence encoding an insulin-like growth factor I and encoding alpha-lactalbumin operably linked to a mammary preferential promoter, wherein descendants of said transgenic mammal express an increased amount of growth factor in their milk and an increased milk volume as compared to control non-transgenic mammals.
A method of increasing the volume of milk and the insulin-like growth factor I content of milk in transgenic nonhuman mammals, said method comprising:
- providing a transgenic non-human mammal having a genome, said genome comprising a heterologous nucleic acid sequence encoding an insulin-like growth factor I and encoding alpha-lactalbumin operably linked to a mammary preferential promoter, wherein said transgenic mammal expresses an increased amount of growth factor in its milk as compared to control non-human transgenic mammals.
A method of increasing the growth factor content of milk in non-human transgenic mammals, said method comprising:
- providing a non-human transgenic mammal having a genome, said genome comprising a heterologous nucleic acid sequence encoding a growth factor gene and encoding alpha-lactalbumin operably linked to a mammary preferential promoter, wherein said transgenic mammal expresses an increased amount of growth factor in its milk as compared to control non-transgenic mammals.
Dependencies are inferred from the claim text.