Optically active epoxy compounds and processes for their production
AssigneeTosoh Corporation
InventorsTakumi Kagawa, Takeshi Kambara, Hideo Sakka, Manabu Yanase
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Abstract
An optically active epoxyenone derivative of the following formula (1): wherein R1 is a methyl group, an ethyl group or a C3-10 branched, linear or cyclic alkyl group, and R2 is a phenyl group, a substituted phenyl group or a tert-butyl group.
Claims9
An optically active epoxyester derivative of the following formula (3):
- wherein R1 is a methyl group, an ethyl group or a C3-10 branched, linear or cyclic alkyl group, and R2 is a phenyl group, a substituted phenyl group or a tert-butyl group, wherein the optical conformation of formula (3) is (2S,3R).
A process for producing an optically active 2,3-epoxy-3-cyclohexylpropionic acid and its ester, which comprises reacting an enzyme having an ability to asymmetrically hydrolyze an ester bond, to a mixture of a (2R,3S)-2,3-epoxy-3-cyclohexylpropionate and a (2S,3R)-2,3-epoxy-3-cyclohexylpropionate, of the 2,3-epoxy-3-cyclohexylpropionate of the following formula (7):
- wherein ring A is a cyclohexyl group which may have a substituent, and R3 is an ester residue, for stereoselective hydrolysis, followed by separation and purification.
Dependencies are inferred from the claim text.