(+)-Trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion
AssigneeUniversite de Montreal
InventorsLisa McKerracher, Maxime Lehmann
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Abstract
The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a candidate Rho family member antagonist agent to permit neuron growth. Candidates which elicit neurite outgrowth from the cultured neurons are thus identified as Rho family antagonists.
Claims8
A method of promoting neural growth, the method comprising delivery to a central nervous system tissue of (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexane.
A method of stimulating regenerative growth of damaged neuronal axons in a patient with traumatic nervous system damage, the method comprising delivering directly at a traumatic lesion site in a nerve in a patient, in an amount effective to suppress Rho family member-mediated inhibition of neuronal axon growth, a Rho family antagonist that antagonizes Rho-associated kinase activity, wherein the antagonist is (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexane.
Dependencies are inferred from the claim text.