Method for monitoring coagulability and hypercoagulable states
AssigneeOklahoma Medical Research Foundation
InventorsShinichiro Kurosawa, Deborah J. Stearns-Kurosawa
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Abstract
The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing effectiveness of anticoagulant therapy. A sEPCR ELISA assay is particularly useful for this purpose. A state of hypercoagulability in patients or normal individuals can also be identified by such an assay.
Claims16
A method for monitoring effective thrombin levels in a human patient undergoing anticoagulant therapy comprising measuring circulating levels of soluble endothelial protein C receptor (sEPCR) of said patient, wherein lowered sEPCR levels relate to lowered effective thrombin activity.
A method for monitoring effectiveness of anticoagulant therapy in a human patient comprising measuring circulating sEPCR levels of said patient, wherein decreases in sEPCR indicate that the anticoagulant therapy is effective.
Dependencies are inferred from the claim text.