Pharmaceutical compositions having appetite suppressant activity
AssigneeCsir
InventorsFanie Retief Van Heerden, Robert Vleggaar, Roelof Marthinus Horak, Robin Alec Learmonth, Vinesh Maharaj, Rory Desmond Whittal
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Abstract
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1)
Claims70
A method of suppressing appetite in a human or animal, comprising administering to said human or animal an appetite-suppressant effective amount of a compound having the structural formula (2)
- wherein:
- R=alkyl;
- R1=H, alkyl, tigloyl, benzoyl, or any other organic ester group;
- R2=H, or one or more 6-deoxy carbohydrates, or one or more 2,6-dideoxy carbohydrates, or glucose molecules, or combinations thereof;
- and
- the broken lines indicate the optional presence of a further bond between C4–G5 or C5–C6.
A method of suppressing appetite in a human or animal, comprising administering to said human or animal an appetite-suppressant effective amount of an extract from a plant of the genus Trichocaulon or the genus Hoodia, wherein said extract comprises a compound having the structural formula (2)
- wherein:
- R=alkyl;
- R1=H, alkyl, tigloyl, benzoyl, or any other organic ester group;
- R2=H, or one or more 6-deoxy carbohydrates, or one or more 2,6-dideoxy carbohydrates, or glucose molecules, or combinations thereof;
- and the broken lines indicate the optional presence of a further bond between C4–C5 or C5–C6.
A method of reducing total calorific intake of a human or animal, comprising administering to said human or animal an appetite-suppressant effective amount of a compound having the structural formula (2)
- wherein:
- R=alkyl;
- R1=H, alkyl, tigloyl, benzoyl, or any other organic ester group;
- R2=H, or one or more 6-deoxy carbohydrates, or one or more 2,6-dideoxy carbohydrates, or glucose molecules, or combinations thereof;
- and
- the broken lines indicate the optional presence of a further bond between C4–C5 or C5–C6.
A method of reducing total calorific intake of a human or animal, comprising administering to said human or animal an appetite-suppressant effective amount of an extract from a plant of the genus Trichocaulon or the genus Hoodia, wherein said extract comprises a compound having the structural formula (2)
- wherein:
- R=alkyl;
- R1=H, alkyl, tigloyl, benzoyl, or any other organic ester group;
- =R2=H, or one or more 6-deoxy carbohydrates, or one or more 2,6-dideoxy carbohydrates, or glucose molecules, or combinations thereof and
- the broken lines indicate the optional presence of a further bond between C4–C5 or C5–C6.
Dependencies are inferred from the claim text.