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US 7,160,719 B2Granted
Bioartificial liver system
AssigneeMayo Foundation for Medical Education and Research
InventorScott L. Nyberg
Life of this patent
Estimating the term…
Abstract
A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.
Claims10
A system for treating blood or plasma from a mammal, said system comprising:
- a) a bioreactor comprising a selectively permeable baffler separating a fluid treatment compartment and a cell compartment;
- b) a cell reservoir in fluid communication with said cell compartment of said bioreactor, wherein said cell reservoir comprises fluid and hepatocyte spheroids in said fluid;
- and
- c) a rocking device in contact with said cell reservoir to induce motion to said fluid,
- wherein said motion results in formation of said hepatocyte spheroids in said cell reservoir and helps maintain said hepatocyte spheroids, and wherein said reservoir comprises 0.5×107 to 5×107 hepatocytes/mL of said fluid.
2 more elements
Dependencies are inferred from the claim text.